Evaluation of a continuous isotope feeding method for measurement of cholesterol absorption in man.
John R. Crouse,Scott M. Grundy +1 more
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TLDR
A new method has been developed for measurement of cholesterol absorption that offers the advantages of simplicity of administration of isotope, ease of analysis of stool samples, and daily repeatability of analysis.About:
This article is published in Journal of Lipid Research.The article was published on 1978-11-01 and is currently open access. It has received 149 citations till now.read more
Citations
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Journal ArticleDOI
Serum plant sterols and their relation to cholesterol absorption.
TL;DR: The findings suggest that, in general, serum levels of noncholesterol sterols are effectively determined by the absorption which in turn is proportionate to the fractional absorption of cholesterol.
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Reduction of Serum Cholesterol in Postmenopausal Women With Previous Myocardial Infarction and Cholesterol Malabsorption Induced by Dietary Sitostanol Ester Margarine Women and Dietary Sitostanol
TL;DR: Dietary use of sitostanol ester margarine normalizes LDL cholesterol in about one third of women with previous myocardial infarction, especially in those with high baseline absorption and low synthesis of cholesterol, and in combination with statins reduces the needed drug dose.
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Cholesterol metabolism during ketoconazole treatment in man.
TL;DR: It appears that ketoconazole inhibits cholesterol elimination as bile acids by blocking 14 alpha-demethylation, which results in effective drainage of sterol nucleus as lanosterols into bile and feces, which is associated with a marked reduction in low density lipoprotein (LDL) cholesterol level probably through activation of hepatic LDL apoB receptors.
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Serum cholesterol and cholesterol and lipoprotein metabolism in hypercholesterolaemic NIDDM patients before and during sitostanol ester-margarine treatment.
Helena Gylling,Tatu A. Miettinen +1 more
TL;DR: It is concluded that the sitostanol ester-induced decrease in cholesterol absorption compensatorily stimulated cholesterol synthesis, had no effect on fractional catabolic rate, but decreased transport rate for LDL apoprotein B so that serum total, VLDL and LDL cholesterol levels were decreased.
References
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Quantitative isolation and gas--liquid chromatographic analysis of total dietary and fecal neutral steroids.
TL;DR: The sensitivity of the method is such that I-g fecal aliquots containing as little as 25 pg of mixed neutral steroids can be analyzed accurately, but the procedure lends itself well to preparative scale work for more definitive study of individual neutral steroids.
Journal Article
Interruption of the enterohepatic circulation of bile acids in man: comparative effects of cholestyramine and ileal exclusion on cholesterol metabolism.
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Effects of polyunsaturated fats on lipid metabolism in patients with hypertriglyceridemia.
TL;DR: Changes in the metabolism of cholesterol, bile acids, and triglycerides in the patients of this study suggests that polyunsaturated fats may cause a lowering of cholesterol through multiple mechanisms, and it seems unlikely that a single action can explain all the effects of these fats on the plasma lipids.
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Quantification of cholesterol absorption in man by fecal analysis after the feeding of a single isotope-labeled meal
TL;DR: The present experiments were undertaken to explore what information could be derived from fecal analysis after a single feeding of meals containing labeled cholesterol, and it was found that the plant sterol &sitosterol is absorbed from the human intestine.
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Determination of cholesterol absorption in man by intestinal perfusion.
Scott M. Grundy,Henry Y.I. Mok +1 more
TL;DR: The intestinal perfusion method appears to provide certain advantages over previous techniques for estimating total cholesterol entering the upper intestine, including that derived from both endogenous and exogenous sources.