Journal ArticleDOI
Evaluation of prenatal diagnosis of congenital heart diseases by ultrasound: experience from 20 European registries
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TLDR
To evaluate prenatal diagnosis of congenital heart diseases by ultrasound investigation in well‐defined European populations with well‐ defined European populations, a large number of patients have been diagnosed with atypical heart disease.Abstract:
Objectives
To evaluate prenatal diagnosis of congenital heart diseases by ultrasound investigation in well-defined European populations.
Design
Data from 20 registries of congenital malformations in 12 European countries were included. The prenatal ultrasound screening programs in the countries ranged from no routine screening to three ultrasound investigations per patient routinely performed.
Results
There were 2454 cases with congenital heart disease with an overall prenatal detection rate of 25%. Termination of pregnancy was performed in 293 cases (12%). There was considerable variation in prenatal detection rate between regions, with the lowest detection rates being in countries without ultrasound screening (11%) and in Eastern European countries (Croatia, Lithuania and Ukraine; 8%). In Western European countries with ultrasound screening, detection rate ranged from 19–48%. There was a significant difference in prenatal detection rate and proportion of induced abortions between isolated congenital heart disease and congenital heart disease associated with chromosome anomalies, multiple malformations and syndromes (P < 0.0001). There were 1694 cases with isolated congenital heart disease of which 16% were diagnosed prenatally. Malformations affecting the size of the ventricles were detected prenatally in half of the cases.
Conclusions
Prenatal detection rate of congenital heart disease varies significantly between countries even with the same screening recommendations. The presence of associated malformations significantly increases the prenatal detection rate. Copyright © 2001 International Society of Ultrasound in Obstetrics and Gynecologyread more
Citations
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Journal ArticleDOI
Diagnosis and Treatment of Fetal Cardiac Disease A Scientific Statement From the American Heart Association
Mary T. Donofrio,Anita J. Moon-Grady,Lisa K. Hornberger,Joshua A. Copel,Mark Sklansky,Alfred Abuhamad,Bettina F. Cuneo,James C. Huhta,Richard A. Jonas,Anita Krishnan,Stephanie Lacey,Wesley Lee,Erik C. Michelfelder,Gwen R. Rempel,Norman H. Silverman,Thomas L. Spray,Janette F. Strasburger,Wayne Tworetzky,Jack Rychik +18 more
TL;DR: This statement highlights what is currently known and recommended on the basis of evidence and experience in the rapidly advancing and highly specialized field of fetal cardiac care.
Journal ArticleDOI
Pulse oximetry screening for critical congenital heart defects in asymptomatic newborn babies: a systematic review and meta-analysis.
TL;DR: Pulse oximetry is highly specific for detection of critical congenital heart defects with moderate sensitivity, that meets criteria for universal screening.
Journal ArticleDOI
Trends in Prenatal Diagnosis, Pregnancy Termination, and Perinatal Mortality of Newborns With Congenital Heart Disease in France, 1983–2000: A Population-Based Evaluation
Babak Khoshnood,Catherine De Vigan,V. Vodovar,J. Goujard,Anne Lhomme,Damien Bonnet,François Goffinet +6 more
TL;DR: Progress in clinical management, together with policies for increased access to prenatal diagnosis, has resulted in both a substantial increase in the prenatal diagnosis and considerable reductions in early neonatal mortality of CHD in the Parisian population.
Journal ArticleDOI
Prenatal diagnosis of severe structural congenital malformations in Europe
E. Garne,Maria Loane,Helen Dolk,C. De Vigan,Gioacchino Scarano,David Tucker,Claude Stoll,Blanca Gener,Anna Pierini,Vera Nelen,C. Rösch,Yves Gillerot,Maria Feijoo,R. Tincheva,Annette Queisser-Luft,Marie-Claude Addor,C. Mosquera,Miriam Gatt,Ingeborg Barišić +18 more
TL;DR: To assess at a population‐based level the frequency with which severe structural congenital malformations are detected prenatally in Europe and the gestational age at detection, and to describe regional variation in these indicators.
Journal ArticleDOI
Global, regional, and national burden of congenital heart disease, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017
Meghan S. Zimmerman,Alison Smith,Craig Sable,Michelle Echko,Lauren B. Wilner,Helen E Olsen,Hagos Tasew Atalay,Ashish Awasthi,Zulfiqar A Bhutta,Jackie Lee Anne Boucher,Franz Castro,Paolo Cortesi,Manisha Dubey,Florian Fischer,Samer Hamidi,Simon I. Hay,Chi Linh Hoang,Christopher Hugo-Hamman,Kathy J. Jenkins,Anita Kar,Ibrahim A Khalil,Raman Krishna Kumar,Gene F. Kwan,Desalegn Tadese Mengistu,Ali H. Mokdad,Mohsen Naghavi,Lemma Negesa,Ionut Negoi,Ruxandra Irina Negoi,Cuong Tat Nguyen,Huong Lan Thi Nguyen,Long Hoang Nguyen,Son Hoang Nguyen,Trang Huyen Nguyen,Molly R Nixon,Jean Jacques Noubiap,Shanti Patel,Emmanuel Peprah,Robert Reiner,Gregory A. Roth,Mohamad-Hani Temsah,Marcos Roberto Tovani-Palone,Jeffrey A. Towbin,Bach Xuan Tran,Tung Thanh Tran,Nu Thi Truong,Theo Vos,Kia Vosoughi,Robert G. Weintraub,Kidu Gidey Weldegwergs,Zoubida Zaidi,Bistra Zheleva,Liesl Zühlke,Christopher J L Murray,Gerard R. Martin,Nicholas J Kassebaum +55 more
TL;DR: The findings highlight the large global inequities in congenital heart disease and can serve as a starting point for policy changes to improve screening, treatment, and data collection.
References
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Detection of transposition of the great arteries in fetuses reduces neonatal morbidity and mortality
Damien Bonnet,Anna Coltri,Gianfranco Butera,Laurent Fermont,Jérôme Le Bidois,Jean Kachaner,Daniel Sidi +6 more
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Journal ArticleDOI
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Journal ArticleDOI
Congenital Heart Defects Natural Course and In Utero Development
Simcha Yagel,Ariel Weissman,Zeev Rotstein,Moshe Manor,Julius Hegesh,Eyal Y. Anteby,Shlomo Lipitz,Reuwen Achiron +7 more
TL;DR: Although most fetal cardiac anomalies are detectable early in gestation, some may evolve in utero at different stages of pregnancy.
Journal ArticleDOI
Comparison of outcome when hypoplastic left heart syndrome and transposition of the great arteries are diagnosed prenatally versus when diagnosis of these two conditions is made only postnatally.
R.Krishna Kumar,R.Krishna Kumar,Jane W. Newburger,Jane W. Newburger,Kimberlee Gauvreau,Kimberlee Gauvreau,Steven A. Kamenir,Steven A. Kamenir,Lisa K. Hornberger,Lisa K. Hornberger +9 more
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