Journal ArticleDOI
Evaluation of surfactant cytotoxicity potential by primary cultures of ocular tissues: I. Characterization of rabbit corneal epithelial cells and initial injury and delayed toxicity studies.
TLDR
In vitro cytotoxicity assays using primary cultures of rabbit corneal epithelial cells may be used to rank the cytotoxic potential of surfactants, but only the lactate dehydrogenase leakage test was able to assess prolonged cell injury.About:
This article is published in Toxicology.The article was published on 1992-11-30. It has received 123 citations till now. The article focuses on the topics: Lactate dehydrogenase & Cytotoxicity.read more
Citations
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Journal ArticleDOI
Biological activity and environmental impact of anionic surfactants
TL;DR: The role of anionic surfactants in the environment is ambiguous: they can cause serous environmental pollution with toxic effect on living organisms; otherwise, they can promote the decomposition and/or removal of other inorganic and organic pollutants from the environment.
Journal ArticleDOI
Surfactants in the Environment
TL;DR: Surfactants in the Environment Surfactants are a diverse group of chemicals that are best known for their wide use in detergents and other cleaning products and most of them end up dispersed in different environmental compartments such as soil, water or sediment.
Journal ArticleDOI
Surfactants: toxicity, remediation and green surfactants
TL;DR: In this article, the safety of surfactants in aquatic systems, in terrestrial ecosystems and for humans is reviewed. But the authors focus on the biodegradation of the anionic detergents sodium dodecyl sulfate and linear alkyl benzene sulfonate.
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An anticancer drug delivery system based on surfactant-templated mesoporous silica nanoparticles.
TL;DR: Three types of surfactant-templated mesoporous silica nanoparticles (Surf@MSNs) of 150-660 nm in diameter were developed as anticancer drug delivery systems and CTAB-contained MSNs show remarkably higher long-term anticancer efficacy than CPT-11-loaded surfactants-free MSNs (CPT@MSNS), even at very low concentrations of 2-15 microg mL(-1).
Journal ArticleDOI
Evaluation of eight in vitro assays for assessing the cytotoxicity of cigarette smoke condensate.
TL;DR: The results of this study indicate the assay that measured membrane integrity was the most sensitive for short exposure times, whereas the neutral red and kenacid blue assays that measured total cell number were more sensitive for longer exposure times.
References
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Journal ArticleDOI
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
TL;DR: This assay is very reproducible and rapid with the dye binding process virtually complete in approximately 2 min with good color stability for 1 hr with little or no interference from cations such as sodium or potassium nor from carbohydrates such as sucrose.
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Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
TL;DR: A tetrazolium salt has been used to develop a quantitative colorimetric assay for mammalian cell survival and proliferation and is used to measure proliferative lymphokines, mitogen stimulations and complement-mediated lysis.
Journal Article
Methods for the study of irritation and toxicity of substances applied topically to the skin and mucous membranes
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Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves.
TL;DR: A general computerized method is developed to describe the dose-response curves in terms of basal and maximal responses, ED50, and curve shape or steepness, which permits rigorous statistical analysis, provides a basis for pooling of information from separate experiments, and allows one to test which characteristics are shared by various curves.
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Differentiation-related expression of a major 64K corneal keratin in vivo and in culture suggests limbal location of corneal epithelial stem cells.
TL;DR: Keratin expression data suggest that the acidic 55K and basic 64K keratins represent markers for an advanced stage of corneal epithelial differentiation.