D
David J. Doolittle
Researcher at R. J. Reynolds Tobacco Company
Publications - 90
Citations - 3728
David J. Doolittle is an academic researcher from R. J. Reynolds Tobacco Company. The author has contributed to research in topics: Sidestream smoke & Tar (tobacco residue). The author has an hindex of 30, co-authored 90 publications receiving 3545 citations. Previous affiliations of David J. Doolittle include Wake Forest University & Michigan State University.
Papers
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Journal ArticleDOI
Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework
Edward J. Calabrese,Kenneth Bachmann,A. John Bailer,P. Michael Bolger,Jonathan Borak,Lu Cai,Nina Cedergreen,M. George Cherian,Chuang Chin Chiueh,Thomas W. Clarkson,Ralph R. Cook,David M. Diamond,David J. Doolittle,Michael A. Dorato,Stephen O. Duke,Ludwig E. Feinendegen,Donald E. Gardner,Ronald W. Hart,Kenneth L. Hastings,A. Wallace Hayes,George R. Hoffmann,John A. Ives,Zbigniew Jaworowski,Thomas E. Johnson,Wayne B. Jonas,Norbert E. Kaminski,John G. Keller,James E. Klaunig,Thomas B. Knudsen,Walter J. Kozumbo,Teresa Lettieri,Shu Zheng Liu,Andre Maisseu,Kenneth I. Maynard,Edward J. Masoro,Roger O. McClellan,Harihara M. Mehendale,Carmel Mothersill,David B. Newlin,Herbert N. Nigg,Frederick W. Oehme,Robert F. Phalen,Martin A. Philbert,Suresh I. S. Rattan,Jim E. Riviere,Joseph Rodricks,Robert M. Sapolsky,Bobby R. Scott,Colin Seymour,David A. Sinclair,Joan Smith-Sonneborn,Elizabeth T. Snow,Linda P. Spear,Donald E. Stevenson,Yolene Thomas,Maurice Tubiana,Gary M. Williams,Mark P. Mattson +57 more
TL;DR: This article offers a set of recommendations that scientists believe can achieve greater conceptual harmony in dose-response terminology, as well as better understanding and communication across the broad spectrum of biological disciplines.
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"IARC group 2B Carcinogens" reported in cigarette mainstream smoke.
TL;DR: Nine chemical compounds of the 50 Group 2A listings have been reported in cigarette mainstream smoke and in micrograms/cigarette (mug/cig), the ranges reported for each of the nine compounds are revealed.
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An international literature survey of “IARC group I carcinogens” reported in mainstream cigarette smoke
TL;DR: Nine of the 44 chemical agents classified as "Group I carcinogens" by IARC have been reported to occur in mainstream cigarette smoke, and several correlations between the yield of a particular chemical in mainstream smoke and certain cigarette characteristics were observed.
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Evaluation of eight in vitro assays for assessing the cytotoxicity of cigarette smoke condensate.
TL;DR: The results of this study indicate the assay that measured membrane integrity was the most sensitive for short exposure times, whereas the neutral red and kenacid blue assays that measured total cell number were more sensitive for longer exposure times.
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A comparison of the mainstream smoke chemistry and mutagenicity of a representative sample of the US cigarette market with two Kentucky reference cigarettes (K1R4F and K1R5F).
T.A Chepiga,Michael J. Morton,P.A Murphy,J.T Avalos,Betsy Bombick,David J. Doolittle,Michael F. Borgerding,James E. Swauger +7 more
TL;DR: Results indicated that, overall, mainstream smoke constituent levels are well predicted by FTC "tar" yield--constituent levels increased as " tar" delivery increased, and support the use of the K1R4F and theK1R5F as acceptable reference cigarettes for comparative mutagenicity and smoke chemistry studies of cigarettes available on the US market.