Journal ArticleDOI
Evidence for Altered Structure and Impaired Mitochondrial Electron Transport Function in Selenium Deficiency
P. Rani,K. Lalitha +1 more
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TLDR
Electron microscopic observations revealed structural changes such as loss of cristae with proliferative and degenerative changes of the mitochondria in Se deficiency and involvement of Se in maintaining structure and functional efficiency of mitochondria is evident from the present study.Abstract:
Selenium (Se) deficiency in the experimental models, Coturnix coturnix japonica and Corcyra cephalonica, resulted in impaired mitochondrial substrate oxidations and lowered thiol levels. Studies with respiratory inhibitors confirmed reduced mitochondrial electron transport enzyme activities, especially at cytochrome c oxidase (COX), the terminal segment. Enhanced mitochondrial lipid peroxidation in Se deficiency was more pronounced in the heart tissue of the quail compared to other tissues. Glutathione peroxidase (GSH-Px) activity toward H2O2 and cumene hydroperoxide were generally low in the insect muscle tissue and activity toward H2O2 was maximal in the quail heart mitochondria that was not very sensitive to Se status. Lowered COX activity in Se deficiency was more directly correlated with the increased level of lipid peroxidation than with the GSH-Px activity measured, suggestive of Se mediated protective mechanisms independent of GSH-Px. Electron microscopic observations revealed structural changes such as loss of cristae with proliferative and degenerative changes of the mitochondria in Se deficiency. Involvement of Se in maintaining structure and functional efficiency of mitochondria is evident from the present study.read more
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References
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Journal ArticleDOI
Tetracyano-2,2-bipyridineiron(iii), an improved electron acceptor for the spectrophotometric assay of beta-oxidation and of succinate dehydrogenase in intact mitochondria.
TL;DR: A recently described direct reading assay for beta-oxidation and for succinate oxidation in intact mitochondria using [Fe(CN)6]3- as final electron acceptor has been improved by using instead tetracyano-2,2-bipyridineiron(III) [Fe (CN)4(bpy)]-, which gives a 2.6 times greater absorbance change on reduction.
Metabolic lesions in dietary necrotic liver degeneration.
TL;DR: In this article, three distinct dietary factors have been identified as protective against necrotic liver degeneration, namely, cystine (2, lo), vitamin E (ll), and Factor 3 (12).
Journal ArticleDOI
Decreased ubiquinone levels in tissues of rats deficient in selenium.
Surasi Vadhanavikit,H.E. Ganther +1 more
TL;DR: It is concluded that Se, as an integral part of the enzyme glutathione peroxidase, may protect tissues from oxidative damage, thereby preserving the ability of the cells to synthesize ubiquinone and preventing ubiquinones from oxidative degradation.
Journal ArticleDOI
Selenium modulates peroxidation in the absence of glutathione peroxidase in Musca domestica.
TL;DR: The authors showed that a 73% decrease in total Se compared to those given 1.0 ppm Se in their drinking water was associated with a 84.4% increase in thiobarbituric acid reactants and a 16.3% increase of conjugated dienes.
Journal ArticleDOI
Copper and Selenium Deficiencies Do Not Enhance the Cardiotoxicity in Rats Due to Chronic Doxorubicin Treatment
TL;DR: The data suggest that the cardiomyopathies caused by doxorubicin and Cu and Se deficiencies have some similarities, but cardiac changes may be related to mechanisms other than lipid peroxidation.