Journal ArticleDOI
Evidence for Altered Structure and Impaired Mitochondrial Electron Transport Function in Selenium Deficiency
P. Rani,K. Lalitha +1 more
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TLDR
Electron microscopic observations revealed structural changes such as loss of cristae with proliferative and degenerative changes of the mitochondria in Se deficiency and involvement of Se in maintaining structure and functional efficiency of mitochondria is evident from the present study.Abstract:
Selenium (Se) deficiency in the experimental models, Coturnix coturnix japonica and Corcyra cephalonica, resulted in impaired mitochondrial substrate oxidations and lowered thiol levels. Studies with respiratory inhibitors confirmed reduced mitochondrial electron transport enzyme activities, especially at cytochrome c oxidase (COX), the terminal segment. Enhanced mitochondrial lipid peroxidation in Se deficiency was more pronounced in the heart tissue of the quail compared to other tissues. Glutathione peroxidase (GSH-Px) activity toward H2O2 and cumene hydroperoxide were generally low in the insect muscle tissue and activity toward H2O2 was maximal in the quail heart mitochondria that was not very sensitive to Se status. Lowered COX activity in Se deficiency was more directly correlated with the increased level of lipid peroxidation than with the GSH-Px activity measured, suggestive of Se mediated protective mechanisms independent of GSH-Px. Electron microscopic observations revealed structural changes such as loss of cristae with proliferative and degenerative changes of the mitochondria in Se deficiency. Involvement of Se in maintaining structure and functional efficiency of mitochondria is evident from the present study.read more
Citations
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Journal ArticleDOI
Oxidative stress during selenium deficiency in seedlings of Trigonella foenum-graecum and mitigation by mimosine. Part I. Hydroperoxide metabolism.
TL;DR: The results including the differential response of GR activity to Se or mimosine supplementation are reflective of an effective reductive environment in Se groups and increased turnover of GSH in the presence of Mimosine.
Journal ArticleDOI
Selenium deficiency impairs corticosterone and leptin responses to adrenocorticotropin in the rat
TL;DR: The goal of this study was to investigate in rats the effects of selenium deficiency and oxidative stress on adrenal function and on leptin concentrations and hypothesized that oxidative stress impairs adrenal steroidogenesis and decreases leptin production in vivo.
Journal ArticleDOI
Oxidative stress during selenium deficiency in seedlings oftrigonella foenum-graecum and mitigation by mimosine
TL;DR: It is demonstrated for the first time that mimosine, a naturally occuring toxic amino acid, could be a beneficial growth factor in concentrations between 0.1 and 0.2 mM.
Selenium nanoparticles role in organ systems functionality and disorder
TL;DR: The intent of this review is to investigate current knowledge of SeNPs interaction with major body organ systems functionality, and Investigated pharmacokinetic parameters ofSeNPs was also reviewed.
Journal ArticleDOI
The effect of Helicobacter pylori eradication on the levels of essential trace elements.
Meng-Chieh Wu,Chun-Yi Huang,Fu-Chen Kuo,Wen-Hung Hsu,Sophie S.W. Wang,Hsiang-Yao Shih,Chung-Jung Liu,Yen-Hsu Chen,Deng-Chyang Wu,Yeou-Lih Huang,Chien-Yu Lu +10 more
TL;DR: H pylori eradication regimen appears to influence the serum selenium concentration (IRB number: KMUH-IRB-20120327) and the serum zinc and copper levels had no significant difference between before and after H. pylora eradication therapies.
References
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Journal ArticleDOI
Tissue sulfhydryl groups
TL;DR: A water-soluble (at pH 8) aromatic disulfide [5,5′-dithiobis(2-nitrobenzoic acid] has been synthesized and shown to be useful for determination of sulfhydryl groups.
Book ChapterDOI
Microsomal lipid peroxidation.
John A. Buege,Steven D. Aust +1 more
TL;DR: This chapter discusses microsomal lipid peroxidation, a complex process known to occur in both plants and animals that involves the formation and propagation of lipid radicals, the uptake of oxygen, a rearrangement of the double bonds in unsaturated lipids, and the eventual destruction of membrane lipids.
Journal ArticleDOI
Glutathione peroxidase activity in selenium-deficient rat liver☆
TL;DR: Two peaks of glutathione peroxidase activity were present in the Sephadex G-150 gel filtration chromatogram of rat liver supernatant when 1.5 mM cumene hydroperoxide was used as substrate, and the second peak represents a second glutathienase activity which catalyzes the destruction of organic hydroperoxides but has little activity toward H 2 O 2 and which persists in severe selenium deficiency.
Journal ArticleDOI
A Simple and Rapid Assay of Oxidative Phosphorylation
Britton Chance,G. R. Williams +1 more