Evidence of Recombination among Enteroviruses
TLDR
Recombination breakpoints were detected in all genomic regions except the capsid protein coding region, suggesting that recombination is a significant and relatively frequent mechanism in the evolution of enterovirus genomes.Abstract:
Human enteroviruses consist of more than 60 serotypes, reflecting a wide range of evolutionary divergence. They have been genetically classified into four clusters on the basis of sequence homology in the coding region of the single-stranded RNA genome. To explore further the genetic relationships between human enteroviruses and to characterize the evolutionary mechanisms responsible for variation, previously sequenced genomes were subjected to detailed comparison. Bootstrap and genetic similarity analyses were used to systematically scan the alignments of complete genomic sequences. Bootstrap analysis provided evidence from an early recombination event at the junction of the 5′ noncoding and coding regions of the progenitors of the current clusters. Analysis within the genetic clusters indicated that enterovirus prototype strains include intraspecies recombinants. Recombination breakpoints were detected in all genomic regions except the capsid protein coding region. Our results suggest that recombination is a significant and relatively frequent mechanism in the evolution of enterovirus genomes.read more
Citations
More filters
Journal ArticleDOI
Genetic diversity and evolution of hepatitis C virus--15 years on.
TL;DR: Two contrasting aspects of conservatism and adaptability provide a fascinating paradigm in which to explore the complex selection pressures that underlie the evolution of HCV and other persistent viruses.
Journal ArticleDOI
Consequences of recombination on traditional phylogenetic analysis.
Mikkel H. Schierup,Jotun Hein +1 more
TL;DR: The shape of a phylogenetic tree reconstructed from sequences evolving under the coalescent with recombination is investigated, finding that the length of terminal branches and the total branch length are larger, and the time to the most recent common ancestor smaller, than for a tree reconstructedFrom sequences evolving with no recombination.
Journal ArticleDOI
An emerging recombinant human enterovirus 71 responsible for the 2008 outbreak of hand foot and mouth disease in Fuyang city of China.
Yan Zhang,Zhen Zhu,Weizhong Yang,Jun Ren,Xiaojuan Tan,Yu Wang,Naiying Mao,Songtao Xu,Shuangli Zhu,Aili Cui,Yong Zhang,Dongmei Yan,Qun Li,Xiao-Ping Dong,Jing Zhang,Yueping Zhao,Junfeng Wan,Zijian Feng,Junling Sun,Shiwen Wang,Dexin Li,Wenbo Xu +21 more
TL;DR: An emerging recombinant HEV71 was responsible for the HFMD outbreak in Fuyang City of China, 2008, and was confirmed as the etiological pathogen of the outbreak.
Journal ArticleDOI
Phylogenetic analysis of the complete genome of 18 Norwalk-like viruses.
Kazuhiko Katayama,Haruko Shirato-Horikoshi,Shigeyuki Kojima,Tsutomu Kageyama,Tomoichiro Oka,Fuminori B. Hoshino,Shuetsu Fukushi,Michiyo Shinohara,Kazue Uchida,Yoshiyuki Suzuki,Takashi Gojobori,Naokazu Takeda +11 more
TL;DR: The clustering based on the capsid N/S domain successfully distinguished the NLV as well as the groupingbased on the antigenicity, as determined by both antigen and antibody ELISAs with recombinant virus-like particles.
Journal ArticleDOI
Enterovirus 68 is associated with respiratory illness and shares biological features with both the enteroviruses and the rhinoviruses.
M. Steven Oberste,Kaija Maher,David P. Schnurr,Mary R. Flemister,Judith Lovchik,Heather Peters,Wendy Sessions,Carol J. Kirk,Nando K. Chatterjee,Susan Fuller,J. Michael Hanauer,Mark A. Pallansch +11 more
TL;DR: It is concluded that EV68 is primarily an agent of respiratory disease and that it shares important biological and molecular properties with both the enteroviruses and the rhinoviraluses.
References
More filters
Journal ArticleDOI
Clustal w: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
TL;DR: The sensitivity of the commonly used progressive multiple sequence alignment method has been greatly improved and modifications are incorporated into a new program, CLUSTAL W, which is freely available.
Journal ArticleDOI
Confidence limits on phylogenies: an approach using the bootstrap.
TL;DR: The recently‐developed statistical method known as the “bootstrap” can be used to place confidence intervals on phylogenies and shows significant evidence for a group if it is defined by three or more characters.
Journal ArticleDOI
Full-Length Human Immunodeficiency Virus Type 1 Genomes from Subtype C-Infected Seroconverters in India, with Evidence of Intersubtype Recombination
Kavita S. Lole,Robert C. Bollinger,Ramesh S. Paranjape,Deepak A. Gadkari,Smita Kulkarni,Nicole G. Novak,Roxann G. Ingersoll,Haynes W. Sheppard,Stuart C. Ray +8 more
TL;DR: Because these clones were obtained from Indian seroconverters, they are likely to facilitate vaccine-related efforts in India by providing potential antigens for vaccine candidates as well as for assays of vaccine responsiveness.
Virus Taxonomy. Seventh Report of the International Committee on Taxomony of Viruses
A. A. Brunt,Gary D Foster +1 more
TL;DR: The first report of wisteria vein mosaic virus in china the face of russia part 2 the facade of power nolia.
Related Papers (5)
Frequency and Dynamics of Recombination within Different Species of Human Enteroviruses
Peter Simmonds,Jon Welch +1 more