Excess of glucocorticoid induces cardiac dysfunction via activating angiotensin II pathway.
Sreerupa Ghose Roy,Priyanka De,Debasri Mukherjee,Vivek Chander,Aditya Konar,Debasish Bandyopadhyay,Arun Bandyopadhyay +6 more
TLDR
The excess of glucocorticoid induces cardiac remodelling and pathophysiolgical changes of the myocardium via angiotensin II signalling pathway.Abstract:
Background: Glucocorticoid is widely used as an anti-inflammatory drug in various diseases however excess of it often causes cardiovascular complications. The present study was undertaken to understanread more
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Melatonin protects against isoproterenol-induced myocardial injury in the rat: Antioxidative mechanisms
Debasri Mukherjee,Sreerupa Ghose Roy,Arun Bandyopadhyay,Aindrila Chattopadhyay,Anjali Basu,Elina Mitra,Arnab Ghosh,Russel J. Reiter,Debasish Bandyopadhyay +8 more
TL;DR: The findings document melatonin’s ability to provide cardio protection at a low pharmacological dose and raises the possibility of this indole being a therapeutic treatment for ischemic heart disease.
Journal ArticleDOI
Protective effect of aqueous Curry leaf (Murraya koenigii) extract against cadmium-induced oxidative stress in rat heart.
Elina Mitra,Arnab Ghosh,Debosree Ghosh,Debasri Mukherjee,Aindrila Chattopadhyay,Santanu Dutta,Sanjib K. Pattari,Debasish Bandyopadhyay +7 more
TL;DR: The studies indicated that the aqueous extract of Curry leaf protects the rat cardiac tissue against cadmium-induced oxidative stress possibly through its antioxidant activity.
Journal Article
Glucocorticoid Excess Induces Superoxide Production in Vascular Endothelial Cells and Elicits Vascular Endothelial Dysfunction
TakahikoIuchi,MasashiAkaike,TakaoMitsui,YasushiOhshima,YasumiShintani,HiroyukiAzuma,ToshioMatsumoto +6 more
TL;DR: Responses in forearm blood flow to reactive hyperemia in 20 GC-treated patients were significantly decreased and intracellular amounts of peroxynitrite significantly increased and those of nitric oxide (NO) decreased, respectively.
Journal ArticleDOI
Melatonin protects against isoproterenol‐induced alterations in cardiac mitochondrial energy‐metabolizing enzymes, apoptotic proteins, and assists in complete recovery from myocardial injury in rats
Debasri Mukherjee,Arnab Ghosh,Arun Bandyopadhyay,Anjali Basu,Santanu Datta,Sanjib K. Pattari,Russel J. Reiter,Debasish Bandyopadhyay +7 more
TL;DR: In this article, the authors explore the effect of melatonin against isoproterenol bitartrate (ISO)-induced rat myocardial injury and test whether melatonin has a role in preventing myocardious injury and recovery when the ISO-induced stress is withdrawn.
Journal ArticleDOI
Glucocorticoids activate the local renin–angiotensin system in bone: possible mechanism for glucocorticoid-induced osteoporosis
TL;DR: Evidence is provided for the role of local RAS is involved in GIOP, and GIOP may be ameliorated by blocking the activation ofLocal RAS in the bone.
References
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