Expression of interleukin‐1β in human breast carcinoma
Liang Jin,Ren Qi Yuan,Alexander Fuchs,Yan Yao,Ansamma Joseph,Ralph H. Schwall,Stuart J. Schnitt,Anthony Guida,Harold M. Hastings,Janet Andres,Gary Turkel,Peter J. Polverini,Itzhak D. Goldberg,Eliot M. Rosen +13 more
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TLDR
In this article, the IL-1β content in tissue extracts from >200 invasive breast carcinomas and smaller numbers of ductal carcinoma in situ (DCIS) and benign lesions was measured by an enzyme-linked immunoadsorbent assay and analyzed to determine whether these values were correlated with the contents of scatter factor (SF) (an invasogenic and angiogenic cytokine), von Willebrand's factor (VWF) (a marker of endothelium), thrombospondin-1 (TSP1), and tumor necrosisAbstract:
BACKGROUND
Interleukin 1β (IL-1β) is a multifunctional cytokine that up-regulates the inflammatory response It is not known whether IL-1β plays a major role in human malignancy To determine whether IL-1β might be involved in breast carcinoma progression, the authors measured the IL-1β content in tissue extracts from >200 invasive breast carcinomas and smaller numbers of ductal carcinoma in situ (DCIS) and benign lesions
METHODS
IL-1β content was measured by an enzyme-linked immunoadsorbent assay and analyzed to determine whether these values were correlated with the contents of scatter factor (SF) (an invasogenic and angiogenic cytokine), von Willebrand's factor (VWF) (a marker of endothelium), thrombospondin-1 (TSP1) (an antiadhesive and antiangiogenic glycoprotein), and tumor necrosis factor-α (TNFα) (another proinflammatory cytokine) Studies were also performed to determine whether IL-1β content was correlated with other pathologic and immunochemical variables that have been utilized or proposed as prognostic indicators for breast carcinoma
RESULTS
The most important findings of these studies were: 1) immunoreactive IL-1β was detected in approximately 90% of invasive breast carcinomas; 2) IL-1β levels were significantly higher in invasive carcinomas than in a group of DCIS and benign lesions; 3) high IL-1β content in invasive carcinomas was significantly associated with higher contents of SF, VWF, and TSP1, but not TNFα; and 4) there was a trend toward higher IL-1β content in invasive carcinomas with a group of other parameters that suggest a biologically more aggressive tumor (estrogen receptor negativity, high tumor grade, p53 positivity, and bcl-2 negativity); and the proportion of invasive tumors with these characteristics was significantly increased in a subgroup of tumors having very high IL-1β content The authors also found a correlation between high IL-1β content and CD68 positivity, suggesting that macrophages may account for some of the IL-1β present in human breast carcinoma tissue
CONCLUSIONS
These findings suggest that significant titers of IL-1β are present within the microenvironment of most breast carcinomas and that a high IL-1β content is often associated with tumor invasiveness and with other pathologic features suggestive of an aggressive tumor biology Cancer 1997; 80:421-34 ©; 1997 American Cancer Societyread more
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The involvement of IL-1 in tumorigenesis, tumor invasiveness, metastasis and tumor-host interactions.
Ron N. Apte,Shahar Dotan,Moshe Elkabets,Malka R. White,Eli Reich,Yaron Carmi,Xiaping Song,Tatyana Dvozkin,Yakov Krelin,Elena Voronov +9 more
TL;DR: It is proposed that membrane-associated IL-1α expressed on malignant cells stimulates anti-tumor immunity and activates inflammation that promotes invasiveness and also induces tumor-mediated suppression, pointing to its feasibility in cancer therapy.
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VCAM-1 promotes osteolytic expansion of indolent bone micrometastasis of breast cancer by engaging α4β1-positive osteoclast progenitors
Xin Lu,Euphemia Mu,Yong Wei,Sabine Riethdorf,Qifeng Yang,Qifeng Yang,Min Yuan,Jun Yan,Yuling Hua,Benjamin Tiede,Xuemin Lu,Bruce G. Haffty,Klaus Pantel,Joan Massagué,Yibin Kang,Yibin Kang +15 more
TL;DR: A bone metastasis dormancy model is characterized to show that aberrant expression of vascular cell adhesion molecule 1 (VCAM-1), in part dependent on the activity of the NF-κB pathway, promotes the transition from indolent micrometastasis to overt metastasis.
Journal ArticleDOI
The role of cytokines in breast cancer development and progression
Marcela Esquivel-Velázquez,Pedro Ostoa-Saloma,Margarita Isabel Palacios-Arreola,Karen Elizabeth Nava-Castro,Julieta Ivonne Castro,Jorge Morales-Montor +5 more
TL;DR: The data here suggest that cytokines play an important role in the regulation of both induction and protection in breast cancer.
Journal ArticleDOI
Oestrogen receptor negative breast cancers exhibit high cytokine content.
Carine Chavey,Frédéric Bibeau,Sophie Gourgou-Bourgade,Sandrine Burlinchon,Florence Boissière,Daniel Laune,Sylvie Roques,Gwendal Lazennec +7 more
TL;DR: It is found that multiple cytokines were overexpressed in oestrogen receptor negative breast carcinoma, and that the three major cytokines – MCP-1, MIP-1β and IL-8 – were correlated with inflammatory cell component, which could account for the aggressiveness of these tumours.
Journal ArticleDOI
Host microenvironment in breast cancer development: inflammatory cells, cytokines and chemokines in breast cancer progression: reciprocal tumor-microenvironment interactions.
TL;DR: The purpose of the present review is to outline the reciprocal interactions that exist between these different elements, and to shed light on their potential involvement in breast cancer development and progression.
References
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