Journal ArticleDOI
Expression of MicroRNA (miR) miR-15a/miR-16-1 Downregulates Expression of BCL-2 Protein in Chronic Lymphocytic Leukemia.
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TLDR
This is the first demonstration that miRNAs can effect post-transcriptional regulation of protein expression in a primary human tumor and suggest that mi RNAs may have potential therapeutic utility in the modulation of pathogenic gene-expression in CLL and other cancers.About:
This article is published in Blood.The article was published on 2006-11-16. It has received 5 citations till now. The article focuses on the topics: Expression vector & microRNA.read more
Citations
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Journal ArticleDOI
Casting Light on Intracellular Tracking of a New Functional Graphene-Based MicroRNA Delivery System by FLIM and Raman Imaging.
Anna Piperno,Antonino Mazzaglia,Angela Scala,Rosamaria Pennisi,Rosamaria Pennisi,Roberto Zagami,Giulia Neri,Serena M. Torcasio,Consolato Rosmini,Placido Mineo,Monica Potara,Monica Focsan,Simion Astilean,Grace Guoying Zhou,Maria Teresa Sciortino +14 more
TL;DR: The theranostic ability of a new fluorescent labeled cationic cyclodextrin-graphene nanoplatform was investigated studying its intracellular trafficking and its ability to deliver plasmid DNA and microRNA, and an unforeseen caveolae-mediated endocytosis internalization pathway was supposed to be driven by physical-chemical features of GCD@Ada-Rhod.
Journal Article
Role of microRNAs on therapy resistance in Non-Hodgkin's lymphoma.
TL;DR: The role of miRNAs associated with chemo-and radiotherapy resistance in NHL is outlined to open novel avenues for lymphoma treatment and improve the prognosis of NHL patients.
Journal ArticleDOI
Co-delivery of miRNA-15a and miRNA-16–1 using cationic PEGylated niosomes downregulates Bcl-2 and induces apoptosis in prostate cancer cells
Maedeh Ghaffari,Seyed Mehdi Kalantar,Mahdie Hemati,Ali Dehghani Firoozabadi,Amir Asri,Ali Shams,Sina Jafari Ghalekohneh,Fateme Haghiralsadat +7 more
TL;DR: In this article, cationic niosomes were designed and optimized with the specific formulation and the physical characteristics, the cytotoxicity, the impact of transfected miRNAs on the expression of the Bcl-2 gene, and the apoptosis rate of the different formulation into prostate cancer cell were determined.
Journal ArticleDOI
Prostate cancer and microRNAs: New insights into apoptosis.
J. K. Gupta,Waleed K. Abdulsahib,Abduladheem Turki Jalil,Zafar Aminov,Fahad I AlSaikhan,Pushpamala Ramaiah,Bagher Farhood +6 more
TL;DR: In this paper , the authors described in detail how apoptosis dysfunction could be involved in prostate cancer processes and additionally, the mechanisms behind miRNAs affect the apoptosis pathways in PCa.
Review Article Role of microRNAs on therapy resistance in Non-Hodgkin's lymphoma
TL;DR: The role of miRNAs associated with chemo- and radiotherapy resistance in NHL is outlined to open novel avenues for lymphoma treat- ment and improve the prognosis of NHL patients.