Extended HLA/complement allele haplotypes: evidence for T/t-like complex in man.
TLDR
In this paper, the distribution of alleles for HLA-A, B, C, D, BF, C2, C4A, and C4B markers were found to occur in haplotypes at frequencies significantly higher than expected.Abstract:
The chromosomal distribution of alleles for HLA-A,-B,-C, and -DR and the serum complement protein alleles of factor B and C2 and C4 was studied in normal Caucasian families. Eight combinations of HLA-B, DR, BF, C2, C4A, and C4B markers were found to occur in haplotypes at frequencies significantly higher than expected. In these combinations, which were defined as extended major histocompatibility complex haplotypes, HLA-A showed limited variation. A possible mechanism for the maintenance of extended haplotypes are human analogs of murine t mutants which are characterized by crossover suppression and male transmission bias. One human 6p haplotype, HLA-B8, DR3, SCO1, GLO 2, was found to be transmitted from males to 83% of their offspring. The same haplotype with GLO 1 had no transmission bias. It is suggested that this GLO 2-marked chromosome is a human analog of a murine t mutant.read more
Citations
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Extreme genetic risk for type 1A diabetes in the post-genome era.
TL;DR: The search for additional MHC loci will require analysis of the remarkable long-range identity of extended MHC haplotypes, and current prediction algorithms will likely be greatly improved for the general population when the additional contributing loci of the MHC are defined.
Journal ArticleDOI
Major-Histocompatibility-Complex Extended Haplotypes in Membranoproliferative Glomerulonephritis
TL;DR: The hypothesis that a specific extended haplotype of the major histocompatibility complex is associated with susceptibility to membranoproliferative glomerulonephritis is supported, and that patients withglomerul onephritis who have this extended haplotypes have a poorer prognosis for kidney survival than those without the haplotype.
Journal ArticleDOI
HLA-linked heat-shock protein 70 (HSP70-2) gene polymorphism and celiac disease.
TL;DR: The data confirm the crucial role of MHC class II in suspectibility to celiac disease, but due to a strong linkage disequilibrium within MHC the role ofMHC class III genes in disease associations can not be ruled out.
Journal ArticleDOI
The study of tumor necrosis factor beta gene polymorphism in lung cancer patients
Tatsuo Shimura,Tatsuo Shimura,Masao Hagihara,Kentaro Takebe,Kentaro Takebe,Batmunkh Munkhbat,Tatsuro Odaka,Harufumi Kato M.D.,Yukio Nagamachi,Kimiyoshi Tsuji +9 more
TL;DR: The genetic background of lung cancer has not yet been precisely clarified and the relationship between the human leukocyte antigen and lung cancer is still unclear.
Book ChapterDOI
Frozen Haplotypes in Mhc Evolution
TL;DR: It is demonstrated that similar DRB haplotype polymorphism exists also in the apes - the chimpanzee and the gorilla.
References
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Journal ArticleDOI
Genetic polymorphism in human glycine-rich beta-glycoprotein.
TL;DR: Electrophoretic studies of fragments from defined types of GBG suggested that GBG cleavage induced by complement or properdin activation in serum occurred through this C moiety, since two variants were detectable in one fragment and two were found in the other fragment.
Journal ArticleDOI
Inherited structural polymorphism of the fourth component of human complement.
Zuheir L. Awdeh,Chester A. Alper +1 more
TL;DR: Close linkage with no crossovers was found between the two C4 loci, allowing the definition of C4AB haplotypes, and between C4 haplotypes and the C2 and BF loci of the human histocompatibility complex.
Journal ArticleDOI
Two HLA-linked loci controlling the fourth component of human complement
TL;DR: Family studies showed that this polymorphism of C4 did not segregate with HLA histocompatibility genes in a fashion governed by two codominant alleles at a single genetic locus, in agreement with the hypothesis that two different genetic loci control the electrophoretic patterns of C 4.
Journal ArticleDOI
Evidence for linkage between HL-A histocompatibility genes and those involved in the synthesis of the second component of complement.
TL;DR: In this paper, a family with C2 deficiency revealed evidence for close linkage between the C2 defect and the histocompatibility HL-A loci, and the possible significance of such linkage was discussed.
Journal ArticleDOI
Linkage of HL-A and GBG.
TL;DR: The HL‐A histocompatibility locus is closely linked to that for the glycinerich β‐glycoprotein polymorphism and no recombinants were seen among 44 children from 12 informative families.
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Inherited structural polymorphism of the fourth component of human complement.
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