Open AccessJournal Article
Fatty acid composition in normozoospermic, asthenozoopermic,asthenoteratozoospermic and oligoasthenoteratozoospermic ejaculates
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TLDR
In this article, the sperm fatty acid analysis was performed using capillary gas chromatography and the results showed that sperm motility and morphology were correlated positively with levels of arachidonic acid and DHA while a negative correlation was observed with stearic acid and oleic acid.Abstract:
Background: The lipids of the spermatozoa membrane are important for the fluidity and flexibility of spermatozoa. However, spermatozoa’s lipids are the main substrates for peroxidation, which may provoke severe functional disorder of sperm.
Objective: The aim of this study was to investigate the fatty acids composition of spermatozoa in men with asthenozoospermia, asthenoteratozoospermia and oligoasthenoteratozoospermia compared with normozoospermic males.
Materials and Methods: A cross-sectional study was designed. The patients were 51 men with seminal parameters abnormalities undergoing infertility screening. The patients were grouped into asthenozoospermic (n=15), asthenoteratozoospermic (n=21) and oligoasthenoteratozoospermic (n=15). The patients were compared with 21 males with normozoospermia. Sperm fatty acid analysis was performed using capillary gas chromatography.
Results: Levels of stearic acid and oleic acid were significantly higher in oligoasthenoteratozoospermic subjects compared with these levels in normozoospermic males. Levels of arachidonic acid and DHA were significantly lower in the sperms of oligoasthenoteratozoospermic males than normozoospermic men. Sperm motility and morphology were correlated positively with levels of arachidonic acid and DHA while a negative correlation was observed with levels of stearic acid and oleic acid.
Conclusion: In conclusion, impaired sperm function can originate from the disorder of sperm lipid metabolism. Low levels of DHA and arachidonic acid in spermatozoa of oligoasthenoteratozoospermic subjects may be the result of breakdown of them.read more
Citations
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Asthenozoospermia and membrane remodeling enzymes: a new role for phospholipase A2.
Carmelina Daniela Anfuso,Melania Olivieri,Salvatore Bellanca,Mario Salmeri,Carla Motta,Marina Scalia,Cristina Satriano,S. La Vignera,Nunziatina Burrello,Nunzia Caporarello,Gabriella Lupo,A. E. Calogero +11 more
TL;DR: Investigating the possible involvement of different isoforms of phospholipase in asthenozoospermia found PLA2s are expressed in different areas of human spermatozoa, and PLA2 expression and/or different distribution could be potential biomarkers of male factor infertility.
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Effects of smoking on fatty acid composition of phospholipid sperm membrane and the malondialdehyde levels in human seminal plasma.
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References
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Differential production of reactive oxygen species by subsets of human spermatozoa at different stages of maturation
Enrique Gil-Guzman,Mario Ollero,Mari C. Lopez,Rakesh Sharma,Juan G. Alvarez,Anthony J. Thomas,Ashok Agarwal +6 more
TL;DR: There is significant cell-to-cell variation in ROS production in subsets of spermatozoa at different stages of maturation and that oxidative damage of mature spermatozosa by ROS-producing immature spermatoza during sperm migration from the seminiferous tubules to the epididymis may be an important cause of male infertility.
Journal ArticleDOI
The fatty acid composition of phospholipids of spermatozoa from infertile patients
TL;DR: Differences in FA composition of PL in subpopulations of human spermatozoa, and in their heads and tails may be related to sperm maturity and to differences in physiological function.
Journal ArticleDOI
Differential Production of Reactive Oxygen Species by Subsets of Human Spermatozoa
TL;DR: The results of this study indicate that there is significant cell-to-cell variation in ROS production in subsets of spermatozoa at different stages of maturation and that oxidative damage of mature spermatoza by ROS-producing immature spermatozosa during sperm migration from the seminiferous tubules to the epididymis may be an important cause of male infertility.
Journal ArticleDOI
Sperm fatty acid composition in subfertile men.
TL;DR: It is suggested that decreased DHA and PUFA, and increased w6/w3 in spermatozoa may be related to infertility in oligo- and/or asthenozoospermic men.
Journal ArticleDOI
Fatty acid analysis of blood serum, seminal plasma, and spermatozoa of normozoospermic vs. asthenozoospermic males.
TL;DR: In asthenozoospermic individuals, lower levels of DHA in the seminal plasma, but not in the blood serum, mimic the decreased concentrations of D HA in the spermatozoa, suggesting that the lower concentrations of spermatozoon DHA is due not to dietary differences but to some type of metabolic difference in the asthenozoopermic men.