Open AccessJournal Article
Fatty acid intake and Kupffer cell function: fish oil alters eicosanoid and monokine production to endotoxin stimulation.
Timothy R. Billiar,Paul E. Bankey,B A Svingen,R D Curran,Michael West,Ralph T. Holman,Richard L. Simmons,F. B. Cerra +7 more
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TLDR
It is shown that prolonged changes in membrane phospholipid content induced by dietary fat source can influence not only PG and Tx production but monokine release as well, and may contribute to the anti-inflammatory effect of diets high in n-3 fatty acids.About:
This article is published in Surgery.The article was published on 1988-08-01 and is currently open access. It has received 253 citations till now. The article focuses on the topics: Fatty acid & Monokine.read more
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n−3 Polyunsaturated fatty acids, inflammation, and inflammatory diseases
TL;DR: At sufficiently high intakes, long-chain n-3 polyunsaturated fatty acids (PUFAs), as found in oily fish and fish oils, decrease the production of inflammatory eicosanoids, cytokines, and reactive oxygen species and the expression of adhesion molecules, and are potentially potent antiinflammatory agents.
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Marine omega-3 fatty acids and inflammatory processes: Effects, mechanisms and clinical relevance
TL;DR: Mechanisms underlying the anti-inflammatory actions of marine n-3 fatty acids include altered cell membrane phospholipid fatty acid composition, disruption of lipid rafts, and inhibition of activation of the pro-inflammatory transcription factor nuclear factor kappa B so reducing expression of inflammatory genes.
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Omega‐3 polyunsaturated fatty acids and inflammatory processes: nutrition or pharmacology?
TL;DR: Animal models demonstrate benefit from n-3 fatty acids in rheumatoid arthritis (RA), inflammatory bowel disease (IBD) and asthma, and clinical trails of fish oil in patients with IBD and asthma are inconsistent with no overall clear evidence of efficacy.
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Polyunsaturated fatty acids, inflammation and immunity
TL;DR: It is possible that these fatty acids might elicit some of their effects by eicosanoid-independent mechanisms, and may be of use as a therapy for acute and chronic inflammation, and for disorders which involve an inappropriately activated immune response.
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Mechanisms of Action of (n-3) Fatty Acids
TL;DR: The very long-chain (n-3) PUFA have a range of physiological roles that relate to optimal cell membrane structure and optimal cell function and responses, and play a key role in preventing, and perhaps treating, many conditions of poor health and well-being.