Journal ArticleDOI
Feline comorbidities: Pathophysiology and management of the obese diabetic cat:
Melissa Clark,Margarethe Hoenig +1 more
TLDR
In this paper, up to 40% of the domestic feline population is overweight or obese and obesity in cats leads to insulin resistance via multiple mechanisms, with each excess kilogram of body weight...Abstract:
Practical relevance:Up to 40% of the domestic feline population is overweight or obese. Obesity in cats leads to insulin resistance via multiple mechanisms, with each excess kilogram of body weight...read more
Citations
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Journal ArticleDOI
Commonly diagnosed disorders in domestic cats in the UK and their associations with sex and age
TL;DR: In this article , a random sample of 18,249 cats was obtained from 1.255,130 cats under primary care during 2019 within VetCompass, an epidemiological research program based on anonymized primary care veterinary clinical records.
Journal ArticleDOI
Commonly diagnosed disorders in domestic cats in the UK and their associations with sex and age
Dan G. O’Neill,Danielle Gunn-Moore,Stephanie Sorrell,Harriet McAuslan,David B. Church,Camilla Pegram,David Brodbelt +6 more
TL;DR: In this paper , a random sample of 18,249 cats was obtained from 1.255,130 cats under primary care during 2019 within VetCompass, an epidemiological research programme based on anonymized primary care veterinary clinical records.
Journal ArticleDOI
Melanocortin-4 receptor and proopiomelanocortin: Candidate genes for obesity in domestic shorthair cats.
TL;DR: In this paper , the association between the previously described MC4R variant and body condition score (BCS), as well as body fat content (%BF) in 89 non-diabetic domestic shorthair cats was investigated.
Journal ArticleDOI
Research of the influence of Melanizol pessaries on background of “chemical” vaginitis in rats
O. V. Dolzhykova,R.F. Yeromenko +1 more
TL;DR: In this article , the therapeutic effect of new pessaries Melanizol based on metronidazole and tea tree oil on the model of "chemical" vaginitis in female rats has been proven.
Journal ArticleDOI
Adipokines as potential biomarkers for type 2 diabetes mellitus in cats
TL;DR: Based on similarities in the pathogenesis of T2 DM between humans and cats, adipokines previously proposed as biomarkers for human T2DM may also serve in the diagnosis of this disease in cats.
References
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Journal ArticleDOI
Insulin signalling and the regulation of glucose and lipid metabolism
Alan R. Saltiel,C. Ronald Kahn +1 more
TL;DR: The epidemic of type 2 diabetes and impaired glucose tolerance is one of the main causes of morbidity and mortality worldwide, and tissues such as muscle, fat and liver become less responsive or resistant to insulin.
Journal ArticleDOI
Inflammation, stress, and diabetes
TL;DR: The molecular and cellular underpinnings of obesity-induced inflammation and the signaling pathways at the intersection of metabolism and inflammation that contribute to diabetes are discussed.
Journal ArticleDOI
Management of Hyperglycemia in Type 2 Diabetes, 2015: A Patient-Centered Approach: Update to a Position Statement of the American Diabetes Association and the European Association for the Study of Diabetes
Silvio E. Inzucchi,Richard M. Bergenstal,John B. Buse,Michaela Diamant,Ele Ferrannini,Michael A. Nauck,Anne L. Peters,Apostolos Tsapas,Richard C. Wender,David R. Matthews +9 more
TL;DR: This briefer article should be read as an addendum to the previous full account on the management of hyperglycemia, which described the need to individualize both treatment targets and treatment strategies with an emphasis on patient-centered care and shared decision making.
Journal ArticleDOI
The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus.
TL;DR: Defects in insulin secretion and insulin action occur early in the pathogenesis of diabetes, and intervention to prevent diabetes should target both abnormalities.
Journal ArticleDOI
Type 2 diabetes mellitus.
Ralph A. DeFronzo,Ele Ferrannini,Leif Groop,Robert R. Henry,William H. Herman,Jens J. Holst,Frank B. Hu,C. Ronald Kahn,Itamar Raz,Gerald I. Shulman,Donald C. Simonson,Marcia A. Testa,Ram Weiss +12 more
TL;DR: The greatest need is for agents that enhance insulin sensitivity, halt the progressive pancreatic β-cell failure that is characteristic of T2DM and prevent or reverse the microvascular complications.