Open Access
Fentanyl, fentanyl analogs and novel synthetic opioids: A comprehensive review - eScholarship
TLDR
Synthetic opioids are an increasingly major public health threat requiring vigilance from multiple fields including law enforcement, government agencies, clinical chemists, pharmacists, and physicians, to name a few, in order to stem its tide.About:
The article was published on 2017-10-01 and is currently open access. It has received 323 citations till now. The article focuses on the topics: Fentanyl.read more
Citations
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Fentanyl test strips as an opioid overdose prevention strategy: Findings from a syringe services program in the Southeastern United States.
Nicholas Peiper,Sarah Elizabeth Duhart Clarke,Louise Vincent,Daniel Ciccarone,Alex H. Kral,Jon E. Zibbell +5 more
TL;DR: Using FTS and receiving a positive test result was associated with changes in drug use behavior and perceptions of overdose safety and may represent an effective addition to current overdose prevention efforts when included with other evidence-based strategies.
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After another decade: LC-MS/MS became routine in clinical diagnostics.
Christoph Seger,Linda Salzmann +1 more
TL;DR: The instrumentation matured significantly, the applications are well understood, and the in vitro diagnostics (IVD) industry is shaping the market by providing assay kits, certified instruments, andThe first laboratory automated LC-MS/MS instruments as an analytical core.
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Designer drugs: mechanism of action and adverse effects
Dino Luethi,Matthias E. Liechti +1 more
TL;DR: Because of their novelty, designer drugs may remain undetected by routine drug screening, thus hampering evaluations of adverse effects.
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Evaluation of a fentanyl drug checking service for clients of a supervised injection facility, Vancouver, Canada
Mohammad Karamouzian,Mohammad Karamouzian,Mohammad Karamouzian,Carolyn Dohoo,Sara Forsting,Ryan McNeil,Ryan McNeil,Thomas Kerr,Thomas Kerr,Mark Lysyshyn,Mark Lysyshyn +10 more
TL;DR: Drug checking at harm reduction facilities such as SIFs might be a feasible intervention that could contribute to preventing overdoses in the context of the current overdose emergency, and intended dose reduction was associated with significantly lower odds of overdose.
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New psychoactive substances: a review and updates:
TL;DR: These four classes of NPS are reviewed, including their chemical structures, mechanism of action, modes of use, intended intoxicant effects, and their associated physical and mental health harms.
References
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Increases in Drug and Opioid-Involved Overdose Deaths - United States, 2010-2015.
TL;DR: In an effort to target prevention strategies to address the rapidly changing epidemic, CDC examined overall drug overdose death rates during 2010-2015 and opioid overdosedeath rates during 2014-2015 by subcategories (natural/semisynthetic opioids, methadone, heroin, and synthetic opioids other than methad one).
Journal Article
The inhibitory effect of fentanyl and other morphine-like analgesics on the warm water induced tail withdrawl reflex in rats.
Janssen Pa,Niemegeers Cj,Dony Jg +2 more
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Intravenous fentanyl kinetics
Deborah A. McClain,Carl C. Hug +1 more
TL;DR: Fentanyl kinetics and excretion in 7 healthy male subjects who were given a 3.2‐ or 6.4‐μg/kg dose of 3H‐fentanyi intravenously and fluctuations in plasma levels may contribute to prolonged and recurrent ventilatory effects of fentanyl.
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Clinical Pharmacokinetics of Fentanyl and its Newer Derivatives
TL;DR: Fentanyl is rightly regarded as having a redistribution-limited duration of action after single or infrequent doses (analogous to thiopentone), but the magnitude of the pharmacokinetic constants reported for fentanyl are remarkably inconsistent even in healthy volunteers.
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Fentanyl Law Enforcement Submissions and Increases in Synthetic Opioid–Involved Overdose Deaths — 27 States, 2013–2014
TL;DR: Increases in synthetic opioid deaths among high-burden states disproportionately involved persons aged 15-44 years and males, a pattern consistent with previously documented IMF-involved deaths.