Journal ArticleDOI
Fertility preservation in women
TLDR
Fertility preservation needs to be completed before chemotherapy and/or irradiation is started and might take 2–3 weeks with established techniques such as embryo or oocyte cryopreservation, but further studies are needed in patients with cancer to confirm the excellent outcomes obtained in patients without cancer or in egg donation programmes.Abstract:
In women, ∼10% of cancers occur in those 90% of girls and young women with diseases that require such treatments. However, these treatments can result in premature ovarian failure, depending on the follicular reserve, the age of the patient and the type and dose of drugs used. This article discusses the different fertility preservation strategies: medical therapy before chemotherapy; ovarian transposition; embryo cryopreservation; oocyte vitrification; and ovarian tissue cryopreservation. The indications, results and risks of these options are discussed. Whether medical therapy should be used to protect the gonads during chemotherapy remains a source of debate. Fertility preservation needs to be completed before chemotherapy and/or irradiation is started and might take 2-3 weeks with established techniques such as embryo or oocyte cryopreservation. Further studies are needed in patients with cancer to confirm the excellent outcomes obtained in patients without cancer or in egg donation programmes. For prepubertal girls or cases where immediate therapy is required, cryopreservation of ovarian tissue is the only available option. Finally, possible future approaches are reviewed, including in vitro maturation of nonantral follicles, the artificial ovary, oogonial stem cells and drugs to prevent follicle loss.read more
Citations
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Journal ArticleDOI
Fertility Preservation in Women
TL;DR: There has been a sharp increase in the demand for fertility preservation, and this review summarizes the indications and current options and describes new techniques and strategies, including those for women with newly diagnosed malignant disease.
Journal ArticleDOI
Intraovarian control of early folliculogenesis
TL;DR: Hippo signaling disruption after ovarian fragmentation, combined with treating ovarian fragments with phosphatase and tensin homolog (PTEN) inhibitors and phosphoinositide-3-kinase stimulators to augment AKT signaling, promote the growth of preantral follicles in patients with primary ovarian insufficiency, leading to a new infertility intervention for such patients.
Journal ArticleDOI
The promise of organ and tissue preservation to transform medicine
Sebastian Giwa,Jedediah K. Lewis,Luis M. Alvarez,Luis M. Alvarez,Luis M. Alvarez,Robert Langer,Alvin E. Roth,George M. Church,James F. Markmann,David H. Sachs,Anil Chandraker,Anil Chandraker,Jason A. Wertheim,Martine Rothblatt,Edward S. Boyden,Elling Eidbo,W. P. Andrew Lee,Bohdan Pomahac,Gerald Brandacher,David M. Weinstock,Gloria D. Elliott,David R. Nelson,Jason P. Acker,Korkut Uygun,Boris Schmalz,Boris Schmalz,Brad P Weegman,Alessandro Tocchio,Greg M Fahy,Kenneth B. Storey,Boris Rubinsky,John C. Bischof,Janet A.W. Elliott,Teresa K. Woodruff,G. John Morris,Utkan Demirci,Kelvin G. M. Brockbank,Erik J. Woods,Robert N. Ben,John G. Baust,Dayong Gao,Barry Fuller,Yoed Rabin,David C. Kravitz,Michael J. Taylor,Michael J. Taylor,Mehmet Toner +46 more
TL;DR: Developments indicate that a new paradigm, integrating multiple existing preservation approaches and new technologies that have flourished in the past 10 years, could transform preservation research.
Journal ArticleDOI
Ovarian cortex transplantation: 60 reported live births brings the success and worldwide expansion of the technique towards routine clinical practice
TL;DR: The success and expansion of ovarian tissue cryopreservation and transplantation as a fertility restoration procedure, with the largest series of 60 live births worldwide reported, is described.
References
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Journal ArticleDOI
Cancer statistics, 2012
TL;DR: The reduction in overall cancer death rates since 1990 in men and 1991 in women translates to the avoidance of about 1,024,400 deaths from cancer, which can be accelerated by applying existing cancer control knowledge across all segments of the population, with an emphasis on those groups in the lowest socioeconomic bracket.
A Systematic Review and Meta-Analysis of Randomized Controlled Trials
TL;DR: The current evidence does not support the routine use of cryotherapy after total knee arthroplasty, and the patient-centered outcomes remain underinvestigated.
Journal ArticleDOI
Livebirth after orthotopic transplantation of cryopreserved ovarian tissue
Jacques Donnez,Marie-Madeleine Dolmans,Dominique Demylle,Pascale Jadoul,Céline Pirard,Jean-Luc Squifflet,Belen Martinez-Madrid,A. Van Langendonckt +7 more
TL;DR: The findings suggest that cryopreservation of ovarian tissue should be offered to all young women diagnosed with cancer and a livebirth after orthotopic autotransplantation of Cryopreserved ovarian tissue is described.