Journal ArticleDOI
Focal epileptiform activity in the brain: detection with spike-related functional MR imaging--preliminary results.
Lorenz Jäger,Konrad J. Werhahn,Alexander Hoffmann,Sophia Berthold,Verena Scholz,J. Weber,Soheyl Noachtar,Maximilian F. Reiser +7 more
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TLDR
Spike-related functional MR imaging is a promising technique for detecting focal epileptic brain activity and is correlated with the site of blood oxygen level-dependent signal increase.Abstract:
The purpose of this study was to develop a spike-related functional magnetic resonance (MR) imaging method to detect epileptic brain activity. Correlations between simultaneous spike-related functional MR imaging and electroencephalographic (EEG) recordings were performed in 10 patients with focal epilepsy. Postprocessing techniques were implemented to eliminate contamination of the EEG recording from ballistocardiography and the echo-planar MR imaging sequence. A diagnostic EEG recording was achieved during functional MR imaging. Spike location correlated with the site of blood oxygen level-dependent signal increase. Spike-related functional MR imaging is a promising technique for detecting focal epileptic brain activity.read more
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Integration of fMRI and simultaneous EEG: towards a comprehensive understanding of localization and time-course of brain activity in target detection
Christoph Mulert,Lorenz Jäger,Robert Schmitt,Patrick Bussfeld,Oliver Pogarell,Hans-Jürgen Möller,Georg Juckel,Ulrich Hegerl +7 more
TL;DR: The results suggest that the combination of EEG and fMRI permits an improved understanding of the spatiotemporal dynamics of brain activity.
Journal ArticleDOI
fMRI activation during spike and wave discharges in idiopathic generalized epilepsy.
Yahya Aghakhani,Andrew P. Bagshaw,Christian Bénar,Colin Hawco,F. Andermann,François Dubeau,Jean Gotman +6 more
TL;DR: The presence of a thalamic BOLD response in most patients provided, for the first time in a group of human patients, confirmation of the evidence ofThalamic involvement seen in animal models, and brings a new light to the pathophysiolocal mechanisms generating GSW.
Journal ArticleDOI
Hemodynamic correlates of epileptiform discharges : An EEG-fMRI study of 63 patients with focal epilepsy
Afraim Salek-Haddadi,Beate Diehl,Khalid Hamandi,Martin Merschhemke,Adam D. Liston,Karl J. Friston,John S. Duncan,David R. Fish,Louis Lemieux +8 more
TL;DR: Using continuous EEG-correlated fMRI, the BOLD signal correlates of interictal epileptic discharges in 63 consecutively recruited patients with focal epilepsy are investigated to provide important new information on the optimal use and interpretation of EEG-fMRI in focal epilepsy.
Journal ArticleDOI
EEG–fMRI of idiopathic and secondarily generalized epilepsies
Khalid Hamandi,Afraim Salek-Haddadi,Helmut Laufs,Adam D. Liston,Karl J. Friston,David R. Fish,John S. Duncan,Louis Lemieux +7 more
TL;DR: The spatial distribution of the cortical fMRI response to GSW in both IGE and SGE involved areas of association cortex that are most active during conscious rest, and reduction of activity in these regions during GSW is consistent with the clinical manifestation of absence seizures.
Journal ArticleDOI
Combining EEG and fMRI: A multimodal tool for epilepsy research
TL;DR: The methodology involved in performing such studies, particularly the challenge of recording a good quality EEG inside the MR scanner while scanning is taking place, and the methods required for the statistical analysis of the combined EEG and fMRI time series are reviewed.
References
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Brain magnetic resonance imaging with contrast dependent on blood oxygenation
TL;DR: In this paper, the authors demonstrate in vivo images of brain microvasculature with image contrast reflecting the blood oxygen level, which can be used to provide in vivo real-time maps of blood oxygenation in the brain under normal physiological conditions.
Brainmagnetic resonance imaging withcontrast dependent on blood oxygenation
TL;DR: It is demonstrated that in vivo images of brain microvasculature with image contrast reflecting the blood oxygen level can be used to provide in vivo real-time maps of blood oxygenation in the brain under normal physiological conditions.
Journal ArticleDOI
Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation.
Kenneth K. Kwong,John W. Belliveau,David A. Chesler,Inna E. Goldberg,Robert M. Weisskoff,Brigitte P. Poncelet,David N. Kennedy,Bernice E. Hoppel,Mark S. Cohen,Robert Turner,Hong-Ming Cheng,Thomas J. Brady,Bruce R. Rosen +12 more
TL;DR: In this paper, a series of images were acquired continuously with the same imaging pulse sequence (either gradient echo or spin-echo inversion recovery) during task activation, and a significant increase in signal intensity (paired t test; P less than 0.001) of 1.8% +/- 0.9% was observed in the primary visual cortex (V1) of seven normal volunteers.
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Intrinsic signal changes accompanying sensory stimulation: functional brain mapping with magnetic resonance imaging
Seiji Ogawa,David W. Tank,Ravi S. Menon,Jutta M. Ellermann,Seong-Gi Kim,Hellmut Merkle,Kamil Ugurbil +6 more
TL;DR: It is reported that visual stimulation produces an easily detectable (5-20%) transient increase in the intensity of water proton magnetic resonance signals in human primary visual cortex in gradient echo images at 4-T magnetic-field strength.