Formation and metabolism in vitro of 5,6-epoxides of cholesterol and beta-sitosterol.
Leif Aringer,Peter Eneroth +1 more
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TLDR
The formation of 5alpha,6alpha- and 5beta,6beta-epoxides of cholesterol and beta-sitosterol in rat liver subcellular fractions has been studied and it is shown that the epoxidation seems to occur only in connection with the nonspecific tissue oxidation of the sterols.About:
This article is published in Journal of Lipid Research.The article was published on 1974-07-01 and is currently open access. It has received 114 citations till now. The article focuses on the topics: Sterol & beta-Sitosterol.read more
Citations
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Free Radical Lipid Peroxidation: Mechanisms and Analysis
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Oxysterols: modulators of cholesterol metabolism and other processes.
TL;DR: This review comprises a detailed and critical assessment of current knowledge regarding the formation, occurrence, metabolism, regulatory properties, and other activities of oxysterols in mammalian systems.
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Linoleic acid peroxidation--the dominant lipid peroxidation process in low density lipoprotein--and its relationship to chronic diseases.
TL;DR: Modern separation and identification methods enable detailed insight in lipid peroxidation (LPO) processes and it is shown that HODEs, derived from LA, hydroxyoctadecadienoic acids (HODEs), surmount other markers of LPO.
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Oxysterols: A world to explore
TL;DR: Current knowledge suggests phytosterol oxidation products may also cause cytotoxic and pro-apoptotic effects, although at higher concentrations than COPs, which is not clear yet.
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Mammalian epoxide hydrolases in xenobiotic metabolism and signalling
TL;DR: Takeaway is that epoxide hydrolases play a central role in the detoxification of genotoxic epoxides and have an important function in the regulation of physiological processes by the control of signalling molecules with an epoxide structure.
References
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Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
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1,2-naphthalene oxide as an intermediate in the microsomal hydroxylation of naphthalene.
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Hepatic epoxide hydrase. Structure-activity relationships for substrates and inhibitors.
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The role of arene oxide-oxepin systems in the metabolism of aromatic substrates. III. Formation of 1,2-naphthalene oxide from naphthalene by liver microsomes
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Liquid-gel chromatography on lipophilic-hydrophobic Sephadex derivatives.
TL;DR: Hydrophobic long-chain alkyl ethers of Sephadex have been synthesized and tested for use in liquid chromatography and should be a useful complement to other chromatographic methods.
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