Journal ArticleDOI
Fosmidomycin analogues as inhibitors of monoterpenoid indole alkaloid production in Catharanthus roseus cells.
TLDR
It is found that these new fosmidomycin analogues inhibited the accumulation of ajmalicine, a marker of monoterpenoid indole alkaloids production in plant cells.About:
This article is published in Phytochemistry.The article was published on 2005-08-01. It has received 17 citations till now. The article focuses on the topics: Fosmidomycin & Ajmalicine.read more
Citations
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Journal ArticleDOI
A raison d'être for two distinct pathways in the early steps of plant isoprenoid biosynthesis?
TL;DR: It can be concluded that in angiosperms, under standard growth conditions, C₂₀-phytyl moieties, C ₃₄-triterpenes and Cℓ-carotenoids are made nearly exclusively within compartmentalized pathways, while mixed origins are widespread for other types of isoprenoid-derived molecules.
Book ChapterDOI
Biological Activity of Aminophosphonic Acids and Their Short Peptides
Barbara Lejczak,Paweł Kafarski +1 more
TL;DR: The biological activity and natural occurrence of aminophosphonic acids were described half a century ago as mentioned in this paper, and since then the chemistry and biology of this class of compounds have developed into the separate field of phosphorus chemistry.
Journal ArticleDOI
Evaluation of fosmidomycin analogs as inhibitors of the Synechocystis sp. PCC6803 1-deoxy-D-xylulose 5-phosphate reductoisomerase.
TL;DR: Analogs of the antibiotic fosmidomycin, an inhibitor of the methylerythritol phosphate pathway to isoprenoids, were synthesized and evaluated against the recombinant Synechocystis sp.
Journal ArticleDOI
Enzyme inhibitor studies reveal complex control of methyl-D-erythritol 4-phosphate (MEP) pathway enzyme expression in Catharanthus roseus.
TL;DR: The present results provide novel insight into the regulation of DXS expression in C. roseus in response to MEP-pathway perturbation and suggest that DXR protein stability may be affected by substrate binding.
Book ChapterDOI
Methylerythritol Phosphate Pathway
TL;DR: The state of the art on the knowledge of the genes and enzymes of the MVA-independent MEP pathway is presented, with perspectives toward the development of new antimicrobial drugs and the regulation of isoprenoid biosynthesis in plants.
References
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Journal ArticleDOI
Palladium-catalyzed cross-coupling reactions of organoboron compounds
Norio Miyaura,Akira Suzuki +1 more
TL;DR: In this paper, a cross-coupling reaction is proposed for coupling 1 -Alkenylboron Derivatives: Synthesis of Conjugated Dienes 6.
Journal ArticleDOI
Nutrient requirements of suspension cultures of soybean root cells.
TL;DR: The nutrient requirements of suspension cultures from soybean root have been investigated, and a simple medium consisting of mineral salts, sucrose, vitamins and 2,4-dichlorophenoxyacetic acid (2, 4- d) has been designed.
Journal ArticleDOI
The Palladium‐Catalyzed Cross‐Coupling Reactions of Organotin Reagents with Organic Electrophiles [New Synthetic Methods (58)]
TL;DR: The cross-coupling of organotin reagents with a variety of organic electrophiles, catalyzed by palladium, provides a novel method for generating a carbon-carbon bond.
Journal ArticleDOI
Recent advances in the cross-coupling reactions of organoboron derivatives with organic electrophiles, 1995–1998
TL;DR: The palladium-catalyzed cross-coupling reaction between organoboron compounds and organic halides or triflates provides a powerful and general methodology for the formation of carbon-carbon bonds as discussed by the authors.
Journal ArticleDOI
Inhibitors of the Nonmevalonate Pathway of Isoprenoid Biosynthesis as Antimalarial Drugs
Hassan Jomaa,Jochen Wiesner,Silke Sanderbrand,Boran Altincicek,Claus Weidemeyer,Martin Hintz,Ivana Türbachova,Matthias Eberl,Johannes Zeidler,Hartmut K. Lichtenthaler,Dominique Soldati,Ewald Beck +11 more
TL;DR: A mevalonate-independent pathway of isoprenoid biosynthesis present in Plasmodium falciparum was shown to represent an effective target for chemotherapy of malaria and the presence of two genes encoding the enzymes DOXP synthase and DOXP reductoisomerase suggests that isoprene biosynthesis in P. falcIParum depends on the DOXP pathway.