FOXM1 functions collaboratively with PLAU to promote gastric cancer progression.
TLDR
FOXM1+PLAU+ can serve as effective prognostic biomarkers and potential therapeutic targets for GC and should be screened for drugs or chemicals that targeting the expression patterns PLAU+FOXM1+ subgroup may exert important clinical impact on GC management.Abstract:
Background: Gastric cancer (GC) is one of the main mortality cause worldwide. Previously, we found Forkhead box protein (FOXM1) or Urokinase-type plasminogen activator (PLAU) are independent prognostic markers of GC. This study aims to explore the combining prognostic efficacy and the potential insights underlying additive effect of FOXM1 to PLAU in GC progression through in-silico analyses. Method: The expression of FOXM1 and PLAU were profiled in 33 cancer types using public data. A merged GC expression dataset containing 598 samples was used for evaluating prognostic significance of FOXM1/PLAU. Gene Set Enrichment Analysis (GSEA) was performed to elucidate the mechanisms underlying FOXM1/PLAU promoted GC progression. The Cancer Genome Atlas (TCGA) was used for analyzing the association between FOXM1/PLAU and tumor immune infiltration. Genomic and proteomic differences between FOXM1+PLAU+ and FOXM1-PLAU- groups were also computed using TCGA GC data. Drugs targeting FOXM1/PLAU associated gene expression pattern was analyzed using LINCs database. Results: FOXM1 and PLAU are overexpressed in 17/33 cancer types including GC. Kaplan-Meier analyses indicate that the FOXM1+PLAU+ subgroup have the worst prognosis, while FOXM1-PLAU- subgroup have the best survival. Bioinformatics analysis indicated that FOXM1+PLAU+ associated genes are enriched in TGF-beta, DNA repair and drug resistance signaling pathways; FOXM1 and PLAU expression are negatively correlated with tumor immune infiltration. Genomic and proteomic differences between FOXM1+PLAU+ and FOXM1-PLAU- groups were presented. Data mining from LINCs suggested several chemicals or drugs that could target the gene expression pattern of FOXM1+PLAU+ patients. Conclusion: FOXM1+PLAU+ can serve as effective prognostic biomarkers and potential therapeutic targets for GC. Due to the additive effect of these two genes, screening for drugs or chemicals that targeting the expression patterns PLAU+FOXM1+ subgroup may exert important clinical impact on GC management.read more
Citations
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PLAU Promotes Cell Proliferation and Epithelial-Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma.
TL;DR: In this paper, the expression, prognosis, function, and coexpression genetic networks of PLAU in head and neck squamous cell carcinoma (HNSCC) were investigated by a series of public bioinformatics tools.
Journal ArticleDOI
Expression and mechanism of exosome-mediated A FOXM1 related long noncoding RNA in gastric cancer.
Yan Zhang,Lin Chen,Xuanting Ye,Zhixiong Wu,Zeyu Zhang,Biaofeng Sun,Hong Fu,Chuangang Fu,Xiaofei Liang,Hong Jiang +9 more
TL;DR: In this paper, the authors investigated the role of FOXM1 related long noncoding RNA (FRLnc1) in exosomes in gastric cancer (GC) and found that FRLnc 1 expression was upregulated in GC cells, tumor tissues, and serum of GC patients.
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High expression of bone morphogenetic protein 1 (BMP1) is associated with a poor survival rate in human gastric cancer, a dataset approaches.
Jahirul Hasnat Rafi,Tamanna Jafar,Mohammad Turhan Pathan,Rumman Reza,Saiful Islam,Israt Jahan Sourna,Rahat Alam,Abdus Samad,Foysal Ahammad,Foysal Ahammad +9 more
TL;DR: This study found higher transcriptional and clinicopathological characteristics expression compared to normal tissues, worsening survival rate in GC and identified and analyzed the co-expressed genes and found that the leukemia inhibitory factor is the most positively correlated gene.
Journal ArticleDOI
Overexpressed PLAU and its potential prognostic value in head and neck squamous cell carcinoma.
Zhexuan Li,Changhan Chen,Juncheng Wang,Ming Wei,Guancheng Liu,Yuexiang Qin,Li She,Yong Liu,Donghai Huang,Yongquan Tian,Gangcai Zhu,Xin Zhang +11 more
TL;DR: In this article, the authors investigated the role of PLAU expression in HNSCC and found that PLAU mRNA was significantly elevated, as opposed to its methylation, in head and neck squamous cell carcinomas.
Journal ArticleDOI
Identification of an Immune-Related Signature for Predicting Prognosis in Patients With Pancreatic Ductal Adenocarcinoma
TL;DR: In this paper, a prognosis-associated immune signature (i.e., PAIS) was developed based on immune-associated genes to predict the overall survival of patients with PDAC.
References
More filters
Journal ArticleDOI
Controlling the false discovery rate: a practical and powerful approach to multiple testing
Yoav Benjamini,Yosef Hochberg +1 more
TL;DR: In this paper, a different approach to problems of multiple significance testing is presented, which calls for controlling the expected proportion of falsely rejected hypotheses -the false discovery rate, which is equivalent to the FWER when all hypotheses are true but is smaller otherwise.
Journal ArticleDOI
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
Aravind Subramanian,Pablo Tamayo,Vamsi K. Mootha,Sayan Mukherjee,Benjamin L. Ebert,Michael A. Gillette,Amanda G. Paulovich,Scott L. Pomeroy,Todd R. Golub,Eric S. Lander,Jill P. Mesirov +10 more
TL;DR: The Gene Set Enrichment Analysis (GSEA) method as discussed by the authors focuses on gene sets, that is, groups of genes that share common biological function, chromosomal location, or regulation.
Journal ArticleDOI
Global cancer statistics, 2012
Lindsey A. Torre,Freddie Bray,Rebecca L. Siegel,Jacques Ferlay,Joannie Lortet-Tieulent,Ahmedin Jemal +5 more
TL;DR: A substantial portion of cancer cases and deaths could be prevented by broadly applying effective prevention measures, such as tobacco control, vaccination, and the use of early detection tests.
Journal ArticleDOI
Cancer statistics, 2017
TL;DR: The American Cancer Society estimates the numbers of new cancer cases and deaths that will occur in the United States in the current year and compiles the most recent data on cancer incidence, mortality, and survival.
Journal ArticleDOI
NCBI GEO: archive for functional genomics data sets—update
Tanya Barrett,Stephen E. Wilhite,Pierre Ledoux,Carlos Evangelista,Irene F. Kim,Maxim Tomashevsky,Kimberly A. Marshall,Katherine Phillippy,Patti M. Sherman,Michelle Holko,Andrey Yefanov,Hye Seung Lee,Naigong Zhang,Cynthia L. Robertson,Nadezhda Serova,Sean Davis,Alexandra Soboleva +16 more
TL;DR: The Gene Expression Omnibus is an international public repository for high-throughput microarray and next-generation sequence functional genomic data sets submitted by the research community and supports archiving of raw data, processed data and metadata which are indexed, cross-linked and searchable.