Journal ArticleDOI
From the Chicago MeetingsSarcopenia
TLDR
Sarcopenia is a term used to define the loss of muscle mass and strength that occurs with aging as mentioned in this paper, and sarcopenia plays a major role in the pathogenesis of frailty and functional impairment.About:
This article is published in Journal of Laboratory and Clinical Medicine.The article was published on 2001-04-01. It has received 741 citations till now. The article focuses on the topics: Sarcopenia & Atrophy.read more
Citations
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Sarcopenia: European consensus on definition and diagnosis Report of the European Working Group on Sarcopenia in Older People
Alfonso J. Cruz-Jentoft,Jean-Pierre Baeyens,Jürgen M. Bauer,Yves Boirie,Tommy Cederholm,Francesco Landi,Finbarr C. Martin,Jean-Pierre Michel,Yves Rolland,Stéphane M. Schneider,Eva Topinkova,Maurits Vandewoude,Mauro Zamboni +12 more
TL;DR: The European Working Group on Sarcopenia in Older People (EWGSOP) developed a practical clinical definition and consensus diagnostic criteria for age-related sarcopenia as discussed by the authors.
Journal ArticleDOI
Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability.
TL;DR: To establish the prevalence of sarc Openia in older Americans and to test the hypothesis that sarcopenia is related to functional impairment and physical disability in older persons is established.
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Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International working group on sarcopenia.
Roger A. Fielding,Bruno Vellas,William J. Evans,Shalender Bhasin,John E. Morley,Anne B. Newman,Gabor Abellan van Kan,Sandrine Andrieu,Juergen M. Bauer,Denis Breuille,Tommy Cederholm,Julie Chandler,Capucine De Meynard,Lorenzo M. Donini,Tamara B. Harris,Aimo Kannt,Florence Keime Guibert,Graziano Onder,Dimitris Papanicolaou,Yves Rolland,Daniel Rooks,Cornel C. Sieber,Elisabeth Souhami,Sjors Verlaan,Mauro Zamboni +24 more
TL;DR: Sarcopenia should be considered in all older patients who present with observed declines in physical function, strength, or overall health, and patients who meet these criteria should further undergo body composition assessment using dual energy x-ray absorptiometry with sarcopenia being defined using currently validated definitions.
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Prevalence and clinical implications of sarcopenic obesity in patients with solid tumours of the respiratory and gastrointestinal tracts: a population-based study.
Carla M. Prado,Jessica R L Lieffers,Linda J. McCargar,Tony Reiman,Michael B. Sawyer,Lisa Martin,Vickie E. Baracos +6 more
TL;DR: Evidence is provided of the great variability of body composition in patients with cancer and links body composition, especially sarcopenic obesity, to clinical implications such as functional status, survival, and potentially, chemotherapy toxicity.
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High prevalence of vitamin D inadequacy and implications for health.
TL;DR: The purposes of this article are to examine the prevalence of vitamin D inadequacy and to review the potential implications for skeletal and extraskeletal health.
References
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Biologic basis for interleukin-1 in disease
TL;DR: This is a lengthy review, with 586 citations chosen to illustrate specific areas of interest rather than a compendium of references, which summarizes what the author considers established or controversial topics linking the biology of IL-1 to mechanisms of disease.
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Epidemiology of Sarcopenia among the Elderly in New Mexico
Richard N. Baumgartner,Kathleen M. Koehler,Dympna Gallagher,Linda J. Romero,Steven B. Heymsfield,Robert Ross,Philip J. Garry,Robert D. Lindeman +7 more
TL;DR: Some of the first estimates of the extent of the public health problem posed by sarcopenia are provided, independent of ethnicity, age, morbidity, obesity, income, and health behaviors.
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Exercise training and nutritional supplementation for physical frailty in very elderly people
Maria A. Fiatarone,Evelyn F. O'Neill,Nancy D. Ryan,Karen M. Clements,Guido R. Solares,Miriam E. Nelson,Susan B. Roberts,Joseph J. Kehayias,Lewis A. Lipsitz,William J. Evans +9 more
TL;DR: High-intensity resistance exercise training is a feasible and effective means of counteracting muscle weakness and physical frailty in very elderly people, in contrast to multi-nutrient supplementation without concomitant exercise, which does not reduce muscle weakness orPhysical frailty.
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IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses.
TL;DR: The studies reveal that endogenous IL-6 plays a crucial antiinflammatory role in both local and systemic acute inflammatory responses by controlling the level of proinflammatory, but not antiinflammatory, cytokines, and that these antiinflammatory activities byIL-6 cannot be compensated for by IL-10 or other IL- 6 family members.
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Human Aging, Muscle Mass, and Fiber Type Composition
TL;DR: Results indicate a gradual decrease in size/volume with advancing age, accompanied by a replacement by fat and connective tissue.