Gastric carcinoma. A pathobiological classification.
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TLDR
This classification provided a simple basis for evaluation of various aspects of gastric cancer and indicated that intestinal metaplasia probably played a role in the development of expanding, but not infiltrative, carcinoma.Abstract:
Gastric carcinomas had various pathological features. Based on patterns of growth and invasiveness, however, they fell into two types; expanding type and infiltrative type. These types were readily recognizable histologically: expanding carcinomas grew en masse and by expansion, resulting in the formation of discrete tumor nodules, whereas in infiltrative carcinoma tumor cells invaded individuality. Both types showed varying degrees of cell maturation, but glands were much more common in expanding carcinoma. The difference in growth pattern was reflected partly by gross appearance of the tumors. These two types of carcinoma appeared to be different in their histogenetic origins. Intestinal metaplasia probably played a role in the development of expanding, but not infiltrative, carcinoma. There were differences also in the sex and age of the patients, survival rate, and epidemiological distribution. Thus, this classification provided a simple basis for evaluation of various aspects of gastric cancer.read more
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p53 expression and prognosis in gastric carcinoma
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Intrinsic subtypes of gastric cancer, based on gene expression pattern, predict survival and respond differently to chemotherapy
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TL;DR: In this article, gene expression profiles for 37 GC cell lines were analyzed to identify intrinsic GC subtypes, which are associated with differences in patient survival times and responses to various standard-of-care cytotoxic drugs.
References
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The two histological main types of gastric carcinoma; diffuse and so-called intestinal-type carcinoma. an attempt at a histo-clinical classification
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Histologic types of gastric carcinoma in high‐ and low‐risk areas
TL;DR: Data presented suggest that these two main histologic types may be connected with different precancerous lesions as a significant proportion of the intestinal type carcinomas arose from intestinal metaplasia of the gastric mucosa, while the diffuse type showed no such origin.
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TL;DR: Most tumor cells, however, showed increased numbers of well‐developed microvilli and large pale mucin granules seen in benign metaplasia, indicating a similar cellular origin.
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Prognostic significance of microscopic structure of gastric carcinomas and their regional lymph nodes.
TL;DR: This study provides further evidence in support of a tumor‐host interaction wherein a significant component of host response is mediated by lymphoreticuloendothelial system.