Journal ArticleDOI
Gastroduodenal Injury: Role of Protective Factors
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TLDR
The interaction of the various mucosal protective components helps maintain structural and functional homeostasis and there is increasing evidence suggesting that the upper GI microbiota plays a crucial role in the defense mechanisms.Abstract:
The gastroduodenal mucosal layer is a complex and dynamic system that functions in an interdependent manner to resist injury. We review and summarize the most updated knowledge about gastroduodenal defense mechanisms and specifically address (a) the mucous barrier, (b) membrane and cellular properties, and vascular, hormonal, and (c) gaseous mediators. Trefoil factor family peptides play a crucial role in cellular restitution by increasing cellular permeability and expression of aquaporin channels, aiding cellular migration and tissue repair. Additionally, evidence suggests that the symptoms of functional dyspepsia may be attributed to alterations in the duodenum, including low-grade inflammation and increased mucosal permeability. The interaction of the various mucosal protective components helps maintain structural and functional homeostasis. There is increasing evidence suggesting that the upper GI microbiota plays a crucial role in the defense mechanisms. However, this warrants further investigation.read more
Citations
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A Review of the Role of Flavonoids in Peptic Ulcer (2010-2020).
Catarina Alves de Lima Serafim,Maria Elaine Cristina Araruna,Edvaldo Balbino Alves Júnior,Margareth de Fátima Formiga Melo Diniz,Clélia Akiko Hiruma-Lima,Leônia Maria Batista +5 more
TL;DR: This review refers to a collection of flavonoids with antiulcer activity in vivo and in vitro models that have been reported to show peptic ulcers activity in experimental models.
Journal ArticleDOI
Protective Effects of Wheat Peptides against Ethanol-Induced Gastric Mucosal Lesions in Rats: Vasodilation and Anti-Inflammation.
TL;DR: In this paper, wheat peptides were used to protect gastric mucosa from ethanol-induced lesions in rats via improving the gastric microcirculation and inhibiting inflammation mediated by the NF-κB signaling transduction pathway.
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Drug discovery strategies for modulating oxidative stress in gastrointestinal disorders
TL;DR: The authors collated and reviewed the appropriate literature published between the 1 January 2015 and 31 March 2020 and provided their expert perspectives on the drug discovery strategies for modulating oxidative stress in gastrointestinal disorders.
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The gastroprotective effect of red propolis extract from Northeastern Brazil and the role of its isolated compounds.
Thaise Boeing,Jennyfer Andrea Aldana Mejía,Gari V. Ccana-Ccapatinta,Marihá Mariott,Rita de Cássia Melo Vilhena de Andrade Fonseca da Silva,Priscila de Souza,Luísa Nathália Bolda Mariano,Graziela Regina Oliveira,Isabelle Moraes da Rocha,Gabriela Altini da Costa,Sérgio Faloni de Andrade,Luisa Mota da Silva,Jairo Kenupp Bastos +12 more
TL;DR: HerP displays gastroprotective property against ethanol/HCl-induced damage, and its effect is dependent on prostaglandins and mucin production, and the compounds MV and MD may have an essential role in the activity of HERP.
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Colostrum Therapy for Human Gastrointestinal Health and Disease.
TL;DR: There is increasing awareness that a broad range of gastrointestinal diseases, and some systemic diseases, are characterized by failure of the mucosal barrier and how it may fail as discussed by the authors, and the evidence for or against efficacy of bovine colostrum in management.
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