Showing papers in "Advanced Drug Delivery Reviews in 2017"

TL;DR: Challenges must be overcome to improve (the cost-effectiveness of) nanomedicine development and translation, and they are key to establishing superior therapies for patients.

TL;DR: Cell type- and target-specific pharmacological intervention to therapeutically induce the deactivation of hepatic stellate cells will enable more effective and less toxic precision antifibrotic therapies.

TL;DR: An overview of the current state of AuNP‐based radiosensitization in the context of the physical, chemical and biological modes of radiosensItization is presented, with design considerations to guide the development of next generation AuNPs for clinical applications.

TL;DR: It is believed that the recent approval of a 3D printed drug product will stimulate continual innovation in pharmaceutical manufacturing technology and highlight how product and process understanding can facilitate the development of a control strategy for different 3D printing methods.

TL;DR: This review aims to introduce readers to various aspects in development and evaluation of TAM-targeted therapeutics in pre-clinical and clinical stages of cancer immunotherapies targeting tumor-associated macrophages.

TL;DR: Mucus is a complex aqueous fluid that owes its viscoelastic, lubricating and hydration properties to the glycoprotein mucin combined with electrolytes, lipids and other smaller proteins.

TL;DR: The recent progress in the design and synthesis of self‐assembling peptide‐drug amphiphiles to construct supramolecular nanomedicine and nanofiber hydrogels for both systemic and topical delivery of active pharmaceutical ingredients is highlighted.

TL;DR: Targeted delivery with tumor‐penetrating peptides has been shown to specifically increase the accumulation of drugs, antibodies and nanotherapeutics in experimental tumors in vivo, and in human tumors ex vivo.

TL;DR: It is hypothesized that there are good and bad collagens in fibrosis and that a change of location alone may change the function from good to bad, and the overall composition of the ECM, especially the relative amounts of the many types of collage changes dramatically during fibrosis progression.

TL;DR: This review analyzes the cancer gene‐delivery cascade and the barriers, the needed nanopro properties and the current strategies for overcoming these barriers, and outlines PEGylation, surface‐charge, size, and stability dilemmas in vector nanoproperties to efficiently accomplish the cancer genes delivery cascade.

TL;DR: It is clear from numerous in vitro and in vivo studies that particle elasticity is an important parameter that can be leveraged to improve blood circulation, tissue targeting, and specific interactions with cells.

TL;DR: It is asserted that proton therapy will be a commonly applied radiotherapy modality for most types of solid cancers in the near future through image-guidance, adaptive radiotherapy, further study of biological properties of protons and the development of novel dose computation and optimization methods.

TL;DR: This review highlights the current thinking in this area and the state of the art in: pharmaceutical multicomponent phase design, the intermolecular interactions in these phases, the implications of these interactions on the material properties and the pharmacokinetics in a patient.

TL;DR: A comprehensive analysis of these new formulations of PTX demonstrates that they are largely clinically equivalent to Abraxane, indicating significant room for development of a superior nano‐formulation of paclitaxel.

TL;DR: Self‐assembled peptide nanostructures have advantages in biocompatibility, stability against enzymatic degradation, encapsulation of hydrophobic drugs, sustained drug release, shear‐thinning viscoelastic properties, and/or adjuvanting properties.

TL;DR: Recent research on the role of the immune system in tissue repair and its potential relevance to scaffold design is discussed and new emerging immune cell types relevant to biomaterial responses and tissue repair are discussed.

TL;DR: This article reviews recent advances of controlled drug delivery using microfluidic platforms which can be implanted in human bodies to control drug release in real time through an on‐demand feedback mechanism.

TL;DR: The high heterogeneity of CSC subclones along with changes of the functional behavior of individual tumors under treatment underlines the importance of the selection of the optimal timepoint(s) of biomarker evaluation, but also provides a potential therapeutic target for combined treatment approaches with irradiation.

TL;DR: The fundamental characteristics and trends observed for pharmaceutical hydrates, solvates and amorphous forms are presented, with special emphasis, on pharmaceutical Hydrates with single and two‐component (i.e. cocrystal) host molecules.

TL;DR: The rationale for oral vaccines is addressed, including key biological and physicochemical considerations for next-generation oral vaccine design.

TL;DR: The history of the development of various PEG‐based mucus‐penetrating particles and PEGylation strategies to achieve muco‐inert PEG coatings on nanoparticle drug carriers for improved drug and gene delivery at mucosal surfaces are summarized.

TL;DR: The growing interest in biosimilar antibodies as affordable versions of therapeutic antibodies may provide alternative treatment options as well potentially decreasing costs and regulatory authorities continue to refine the requirements for demonstrating quality, efficacy and safety of biosimilar compared to originator products.

TL;DR: Macrophage‐based therapies are reviewed, focusing on the translational potential for cell delivery of ex vivo‐activated macrophage and delivery of molecules and biomaterials to modulate accumulation and phenotype of endogenous macrophages.

TL;DR: Mechanisms of toxicity for clinically‐relevant immunotherapeutics are reviewed, and approaches based in drug delivery technology to enhance the safety and potency of these treatments are discussed.

TL;DR: This review classify the evolution of advanced drug delivery strategies based on generations and provide a comprehensive overview of transdermal drug delivery technology, highlighting the recent progress in advanced diagnosis and therapy through customized drug delivery systems based on real‐time analysis of physiological cues.

TL;DR: The development of nanoparticles as drug carriers for improving the penetration and bioavailability of drugs to the anterior segment of the eye is summarized.

TL;DR: The fundamental principles of non‐eluting heparin coatings, mechanisms of action, and clinical applications with focus on those technologies which have been commercialized are described.

TL;DR: Exemplary studies showing that pharmacological and physical vessel modulation strategies can be used to improve tumor-targeted drug delivery are summarized, and how these advanced combination regimens can be optimally employed to enhance the (pre-) clinical performance of tumor- targeted nanomedicines is discussed.

TL;DR: The state‐of‐the‐art on this subject is offered in order to develop new insights and to promote cooperative efforts in the fascinating field of API salt and cocrystal forms.

TL;DR: The heterogeneity of mucus components offers a wide range of potential chemical interaction sites for macromolecules, while the mesh‐like architecture given to mucus by the intermolecular cross‐linking of mucin molecules results in a dense network that physically, and in a size‐dependent manner, hinders the diffusion of nanoparticles through mucus.