Gender Differences and Postoperative Delirium in Adult Patients Undergoing Cardiac Valve Surgery
TLDR
In this paper, the effect of gender differences on postoperative delirium (POD) occurrence in adult patients after cardiac valve surgery was investigated, and a multivariate logistic regression with odds ratio and 95% confidence interval (CI) was used to identify the independent risk factors.Abstract:
Background: Postoperative delirium (POD) is common in patients following cardiac surgery. According to studies on non-cardiac surgery, males suffered from higher incidence of POD. However, there is no report about effect of gender differences on POD occurrence in cardiac surgery patients. The aim of this study was to investigate the effect of gender differences on POD occurrence in adult patients after cardiac valve surgery. Methods: This is a retrospective case-control study. We recorded the clinical data in adult patients who underwent elective cardiac valve surgery from May 2019 to October 2020. Univariate analysis was used to screen the potential risk factors. Collinearity analysis was conducted to detect overlapping predictor variables on the outcomes. A multivariate logistic regression with odds ratio (OR) and 95% confidence interval (CI) was used to identify the independent risk factors. The Hosmer-Lemeshow test was performed to show the good calibration of the logistic regression model. Results: In total, we recorded the perioperative data in 431 adult patients, including 212 males and 219 females. 60 patients suffered from POD, including 39 males and 21 females. 20 perioperative variables were selected, and ten were screened by univariate analysis. We did not detect the severe collinearity among the ten variables. Male gender was identified as a significant risk factor in POD occurrence in patients undergoing cardiac surgery (Adjusted OR: 2.38, 95% CI: 1.15 to 4.95, P=0.02). The Hosmer-Lemeshow test demonstrated good calibration of the logistic regression model (χ2=7.70, P=0.463). Besides, compared with females, the relationship of male and delirium subtypes was as follows: 1) hyperactive: adjusted OR: 3.33, 95% CI: 1.35 to 8.24, P=0.009; 2) hypoactive: adjusted OR: 0.55, 95% CI: 0.16 to 1.86, P=0.335; 3) mixed: adjusted OR: 4.95, 95% CI: 0.32 to 77.4, P=0.254. Conclusions: Male gender is an important risk factor in POD occurrence in patients following cardiac surgery. Furthermore, the incidence of hyperactive delirium is higher in males.read more
Citations
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The Impact of Perioperative and Predisposing Risk Factors on the Development of Postoperative Delirium and a Possible Gender Difference
TL;DR: Perioperative and predisposing risk factors had an impact on the development of postoperative delirium and the influence of male sex should be considered in future research.
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The Effect of General Anesthesia vs. Regional Anesthesia on Postoperative Delirium—A Systematic Review and Meta-Analysis
TL;DR: This meta-analysis could not identify that GA was significantly associated with POD occurrence in surgical patients compared with RA, and the pooled result using random-effects model with OR demonstrated significant difference in POD incidence.
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Continuous field flooding versus final one-shot CO2 insufflation in minimally invasive mitral valve repair
Giuseppe Nasso,Ignazio Condello,Giuseppe Santarpino,Nicola Di Bari,Marco Moscarelli,Felice Eugenio Agrò,Roberto Lorusso,Giuseppe Speziale +7 more
TL;DR: In this article , the authors show that continuous field flooding of CO2 in minimally invasive mitral valve repair (MIMVR) patients is associated with a lower incidence of micro-emboli and of agitation at discontinuation of anesthesia, along with improved mechanical ventilation (MV) duration and ICU length of stay.
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Delirium-related factors and their prognostic value in patients undergoing craniotomy for brain metastasis
Jihwan Yoo,Bio Joo,Juyeong Park,Hun Ho Park,Mina Park,Sung Jun Ahn,Sang Hyun Suh,Jae-Jin Kim,Jooyoung Oh +8 more
TL;DR: Postoperative hematoma was identified as a strong predictor of postoperativedelirium and the negative impact of delirium on patient prognosis including low survival rate was confirmed.
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