Genomic architecture of bovine κ-casein and β-lactoglobulin.
R. Gambra,Francisco Peñagaricano,Jenna Kropp,Karam Khateeb,Kent A. Weigel,John A. Lucey,Hasan Khatib +6 more
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TLDR
Analysis of the genetic architecture underlying the absolute concentrations of 2 important milk proteins in a backcross population of (Holstein × Jersey) × Holstein cattle revealed that κ-CN and β-LG production is regulated by both kinase and phosphatase activity, including mechanisms regulating the extracellular matrix.About:
This article is published in Journal of Dairy Science.The article was published on 2013-08-01 and is currently open access. It has received 30 citations till now. The article focuses on the topics: Single-nucleotide polymorphism.read more
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Unravelling the genomic architecture of bull fertility in Holstein cattle.
Yi Han,Francisco Peñagaricano +1 more
TL;DR: A comprehensive genomic analysis in order to unravel the genomic architecture underlying sire fertility in Holstein dairy cattle revealed many significant functional terms, including fertilization, sperm motility, calcium channel regulation, and SNARE proteins.
Journal ArticleDOI
Predicting bull fertility using genomic data and biological information.
TL;DR: The findings suggest that genomic prediction of bull fertility is feasible in dairy cattle and provides potential for accurate genome-guided decisions, such as early culling of bull calves with low SCR predictions.
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Sequence-based GWAS, network and pathway analyses reveal genes co-associated with milk cheese-making properties and milk composition in Montbéliarde cows
Marie Pierre Sanchez,Yuliaxis Ramayo-Caldas,Valérie Wolf,C. Laithier,Mohammed El Jabri,Alexis Michenet,Mekki Boussaha,Sébastien Taussat,Sébastien Fritz,Agnès Delacroix-Buchet,Mickael Brochard,Didier Boichard +11 more
TL;DR: By using an approach that integrated GWAS with network and pathway analyses at the whole-genome sequence level, candidate variants that explain a substantial proportion of the phenotypic variance of CMP traits could be included in genomic evaluation models to improve milk CMP in Montbéliarde cows.
Journal ArticleDOI
Integration of GWAS, pathway and network analyses reveals novel mechanistic insights into the synthesis of milk proteins in dairy cows
Sara Pegolo,Núria Mach,Yuliaxis Ramayo-Caldas,Stefano Schiavon,Giovanni Bittante,Alessio Cecchinato +5 more
TL;DR: Gene-set analysis and the network-based Associated Weight Matrix approach revealed that the milk proteins associated genes were involved in several biological functions, particularly ion and cation transmembrane transporter activity and neuronal and hormone signalling, according to the structure and function of casein micelles.
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Genetic dissection of bull fertility in US Jersey dairy cattle.
Fernanda Marcondes de Rezende,Fernanda Marcondes de Rezende,G. O. Dietsch,Francisco Peñagaricano +3 more
TL;DR: The genetic architecture of sire fertility in US Jersey cattle is dissected to unravel genetic variants and pathways affecting Jersey bull fertility and may contribute to the development of novel genomic strategies for improving sireertility in Jersey cattle.
References
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M Ashburner,Catherine A. Ball,Judith A. Blake,David Botstein,Heather Butler,J. M. Cherry,Allan Peter Davis,Kara Dolinski,Selina S. Dwight,J.T. Eppig,Midori A. Harris,David P. Hill,Laurie Issel-Tarver,Andrew Kasarskis,Suzanna E. Lewis,John C. Matese,Joel E. Richardson,M. Ringwald,Gerald M. Rubin,Gavin Sherlock +19 more
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