P
Poorani Subramanian
Researcher at University of Maryland, College Park
Publications - 27
Citations - 1893
Poorani Subramanian is an academic researcher from University of Maryland, College Park. The author has contributed to research in topics: Microbiome & Medicine. The author has an hindex of 12, co-authored 20 publications receiving 1547 citations.
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Journal ArticleDOI
A whole-genome assembly of the domestic cow, Bos taurus
Aleksey V. Zimin,Arthur L. Delcher,Liliana Florea,David R. Kelley,Michael C. Schatz,Daniela Puiu,Finnian Hanrahan,Geo Pertea,Curtis P. Van Tassell,Tad S. Sonstegard,Guillaume Marçais,Michael Roberts,Poorani Subramanian,James A. Yorke,Steven L. Salzberg +14 more
TL;DR: By using independent mapping data and conserved synteny between the cow and human genomes, this work was able to construct an assembly with excellent large-scale contiguity in which a large majority (approximately 91%) of the genome has been placed onto the 30 B. taurus chromosomes.
Journal ArticleDOI
Comprehensive benchmarking and ensemble approaches for metagenomic classifiers.
Alexa B. R. McIntyre,Rachid Ounit,Ebrahim Afshinnekoo,Ebrahim Afshinnekoo,Robert J. Prill,Elizabeth Henaff,Noah Alexander,Samuel S. Minot,David Danko,Jonathan Foox,Sofia Ahsanuddin,Scott Tighe,Nur A. Hasan,Poorani Subramanian,Kelly Moffat,Shawn Levy,Stefano Lonardi,Nick Greenfield,Rita R. Colwell,Gail L. Rosen,Christopher E. Mason +20 more
TL;DR: It is shown that proper experimental design and analysis parameters can reduce false positives, provide greater resolution of species in complex metagenomic samples, and improve the interpretation of results.
Journal ArticleDOI
Enrichment dynamics of Listeria monocytogenes and the associated microbiome from naturally contaminated ice cream linked to a listeriosis outbreak.
Andrea Ottesen,Padmini Ramachandran,Elizabeth Reed,James R. White,Nur A. Hasan,Poorani Subramanian,Gina Ryan,Karen G. Jarvis,Christopher J. Grim,Ninalynn Daquiqan,Darcy E. Hanes,Marc W. Allard,Rita R. Colwell,Eric W. Brown,Yi Chen +14 more
TL;DR: The draft assembly of a consensus genome of L. monocytogenes from shotgun metagenomic data demonstrated the potential utility of this approach to expedite trace-back of outbreak-associated strains, although further validation will be needed to confirm this utility.
Journal ArticleDOI
The microbiomes of blowflies and houseflies as bacterial transmission reservoirs
Ana Carolina M. Junqueira,Ana Carolina M. Junqueira,Aakrosh Ratan,Enzo Acerbi,Daniela I. Drautz-Moses,Balakrishnan N. V. Premkrishnan,Paul I. Costea,Bodo Linz,Rikky W. Purbojati,Daniel F. Paulo,Nicolas E. Gaultier,Poorani Subramanian,Nur A. Hasan,Rita R. Colwell,Rita R. Colwell,Peer Bork,Ana Maria Lima de Azeredo-Espin,Donald A. Bryant,Donald A. Bryant,Stephan C. Schuster +19 more
TL;DR: The environmental sequencing approach presented here detected a stochastic distribution of human pathogens, such as Helicobacter pylori, thereby demonstrating the potential of flies as proxies for environmental and public health surveillance.
Journal ArticleDOI
Development of SYN-004, an oral beta-lactamase treatment to protect the gut microbiome from antibiotic-mediated damage and prevent Clostridium difficile infection.
Michael Kaleko,J. Andrew Bristol,Steven Hubert,Todd Parsley,Giovanni Widmer,Saul Tzipori,Poorani Subramanian,Nur A. Hasan,Perrti Koski,John F. Kokai-Kun,Joseph Sliman,Annie Jones,Sheila Connelly +12 more
TL;DR: The preclinical development and early clinical studies of the beta-lactamase enzymes, P3A, currently referred to as SYN-004, and its precursor, P1A are presented, designed as orally-delivered, non-systemically available therapeutics for use with intravenous beta- lactam antibiotics.