Journal ArticleDOI
Genotoxic effect of arecoline given either by the peritoneal or oral route in murine bone marrow cells and the influence of N-acetylcysteine.
Anupam Chatterjee,Shampa Deb +1 more
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The data indicate that ARC-OA induced a higher frequency of cancers, a greater delay in the cell cycle and greater sister chromatid exchanges than ARC-IP.About:
This article is published in Cancer Letters.The article was published on 1999-05-03. It has received 33 citations till now. The article focuses on the topics: Arecoline & Sister chromatid exchange.read more
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Role of areca nut in betel quid-associated chemical carcinogenesis: current awareness and future perspectives
TL;DR: It would appear that AN toxicity is not completely due to its polyphenol, tannin and alkaloid content, and further studies are needed to delineate the metabolism of AN ingredient and their roles in the multi-step chemical carcinogenesis, to enhance the success of the future chemoprevention of oral cancer and oral submucous fibrosis.
Journal ArticleDOI
A review of the systemic adverse effects of areca nut or betel nut.
TL;DR: There is an urgent need to recognize areca nut as a harmful food substance by the policy makers and prohibit its glamorization as a mouth freshener and strict laws are necessary to regulate the production of commercial preparations of areca Nut.
Journal ArticleDOI
Betel nut and tobacco chewing; potential risk factors of cancer of oesophagus in Assam, India
TL;DR: There were significant trends in risk ratios associated with the frequency of chewing each day, with the duration of chewing in years and with the age at which the habit was started that were apparent for both males and females and which remained significant after allowance was made for other known risk factors.
Journal ArticleDOI
The pharmacology, toxicology and potential applications of arecoline: a review
TL;DR: Arecoline has great potential to be a therapeutic drug for various ailments, however, further investigations are needed in the future to reduce or eliminate its toxicities before developing into new drug.
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Cell-mediated immunity and head and neck cancer: with special emphasis on betel quid chewing habit.
TL;DR: To elucidate how virus infection, tobacco, alcohol and BQ consumption, and other environmental exposure affect the immune status of patients with oral premalignant lesions or OC will help to understand the immunopathogenesis of OC and to develop immunotherapeutic strategies for OC.
References
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Journal Article
High levels of p53 protein in UV-irradiated normal human skin.
TL;DR: The accumulation of high levels of p53 and PCNA in response to UV doses to which many human populations are routinely exposed provides strong support for a model in which normal p53 acts as part of the DNA damage response in vertebrate cells.
Journal ArticleDOI
Considerations for population monitoring using cytogenetic techniques
Journal Article
Involvement of the p53 tumor suppressor in repair of u.v.-type DNA damage
TL;DR: It is shown that disruption of normal p53 function in human colon carcinoma RKO cells with either the human papillomavirus E6 oncoprotein or a dominant-negative mutant p53 transgene results in reduced repair of u.v.-induced DNA damage and that this process is inducible by DNA damage.
Journal Article
Induction of Lung and Exocrine Pancreas Tumors in F344 Rats by Tobacco-specific and Areca-derived N-Nitrosamines
TL;DR: The observation of benign and malignant tumors of the lung and pancreas of rats treated with the tobacco-specific nitrosamines NNK and NNAL is discussed in respect to the causal association between cigarette smoking and cancer of the Lung and Pancreas.
Related Papers (5)
Influence of buthionine sulfoximine and reduced glutathione on arecoline-induced chromosomal damage and sister chromatid exchange in mouse bone marrow cells in vivo
Satamita Deb,Anirban Chatterjee +1 more