Gingival crevicular fluid levels of monocyte chemoattractant protein-1 in patients with aggressive periodontitis.

TLDR: Investigation of gingival crevicular fluid levels of monocyte chemoattractant protein (MCP)-1 in aggressive periodontitis reveals that MCP-1 can be used to understand the disease pathogenesis of LAgP and GAgP.

Abstract: OBJECTIVES The purpose of this study was to investigate the gingival crevicular fluid (GCF) levels of monocyte chemoattractant protein (MCP)-1 in aggressive periodontitis (AgP) and whether GCF MCP-1 levels differ among localized (L) AgP and generalized (G) AgP. MATERIAL AND METHODS A total of 160 subjects including 80 AgP and 80 age- and gender-matched periodontally healthy (H) controls were recruited in this cross-sectional study (NCT02927704). GCF samples were collected from 160 patients including 50 LAgP, 30 GAgP, and 80 H. Volume of GCF was measured by Periotron 8000® , and enzyme-linked immunosorbent assay was used to assess MCP-1 levels. RESULTS Compared to H controls, all clinical parameters and total amounts (pg 30 s-1 ) of MCP-1 were significantly higher in subjects with LAgP and GAgP (P   0.05), total amounts of MCP-1 were higher in GAgP than LAgP (P < 0.05). CONCLUSION It can be concluded that the total amount of MCP-1 level in GCF may be a potential determinant in AgP subjects. Increased MCP-1 levels in line with the degree of periodontal destruction in GAgP patients reveal that MCP-1 can be used to understand the disease pathogenesis of LAgP and GAgP.