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Glucose-lowering effects of Momordica charantia (Karela) extract in diabetic rats
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Momordica charantia has a glucose-lowering effect in diabetic rats within 14 days of administration, and also prevents fluctuations in FBG levels, and thus has potential therapeutic use in diabetes management.Abstract:
Background: Momordica charantia (MC) is a plant commonly used for both its nutritional and glucose-lowering effects. It has however not been fully validated in diabetes management due to insufficient empirical evidence. The current study thus investigated its effects on blood glucose levels in diabetic rats. Method: Fourteen six-month old, alloxan-induced diabetic Sprague Dawley rats weighing between 200 – 250 g were assigned to two equal groups (control and experimental). Momordica charantia juice extract was administered (10ml/kg) to the experimental group for 28 consecutive days. An equal dose of normal saline was administered to the controls. Fasting blood glucose (FBG) levels were assessed once weekly for 4 consecutive weeks. Thereafter, intraperitoneal glucose tolerance test (IPGTT) was performed. Results: The experimental group achieved normal glucose levels within 14 days of MC administration. At day 28, FBG levels were significantly lower in the experimental group compared to the control (3.27±0.20 vs. 7.59±1.26 mmol/l, p=0.01). In IPGTT, FBG levels were significantly lower in the experimental group compared to the control through the 180 minute period of observation. Conclusion: Momordica charantia has a glucose-lowering effect in diabetic rats within 14 days of administration. It also prevents fluctuations in FBG levels, and thus has potential therapeutic use in diabetes management.read more
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References
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TL;DR: These predictions, based on a larger number of studies than previous estimates, indicate a growing burden of diabetes, particularly in developing countries.
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Economic costs of diabetes in the US in 2002.
TL;DR: In this paper, the authors estimated the direct medical and indirect productivity-related costs attributable to diabetes and calculated and compared the total and per capita medical expenditures for people with and without diabetes.
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Economic Costs of Diabetes in the U.S. in 2002
TL;DR: The authors in this article estimated the direct medical and indirect productivity-related costs attributable to diabetes and calculated the total and per capita medical expenditures for people with and without diabetes in the United States.
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Traditional Plant Medicines as Treatments for Diabetes
Clifford J. Bailey,Caroline Day +1 more
TL;DR: Traditional treatments for diabetes mellitus may provide valuable clues for the development of new oral hypoglycemic agents and simple dietary adjuncts.