Gonadotropin-releasing hormone agonist trigger increases the number of oocytes and embryos available for cryopreservation in cancer patients undergoing ovarian stimulation for fertility preservation
Nigel Pereira,A.G. Kelly,Logan D. Stone,Justine D. Witzke,Jovana P. Lekovich,Rony T. Elias,Glenn L. Schattman,Zev Rosenwaks +7 more
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TLDR
Utilization of a GnRH-agonist trigger increases the number of MII oocytes and 2PN embryos available for cryopreservation in cancer patients undergoing COS for fertility preservation, irrespective of cancer and COS protocol type.About:
This article is published in Fertility and Sterility.The article was published on 2017-09-01 and is currently open access. It has received 31 citations till now. The article focuses on the topics: Embryo cryopreservation & Fertility preservation.read more
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Efficacy and safety of controlled ovarian stimulation using GnRH antagonist protocols for emergency fertility preservation in young women with breast cancer-a prospective nationwide Swedish multicenter study.
Anna Marklund,Sandra Eloranta,Ida Wikander,Margareta Laczna Kitlinski,Mikael Lood,Elizabeth Nedstrand,Ann Thurin-Kjellberg,Pu Zhang,Jonas Bergh,Jonas Bergh,Kenny A. Rodriguez-Wallberg,Kenny A. Rodriguez-Wallberg +11 more
TL;DR: The results of this study support the premise that recently introduced potential improvements to COS protocols for FP in women with BC are efficacious and safe.
Journal ArticleDOI
Management Strategies for POSEIDON Groups 3 and 4.
Thor Haahr,Carlos Dosouto,C. Alviggi,C. Alviggi,Sandro C. Esteves,Sandro C. Esteves,Peter Humaidan +6 more
TL;DR: Both POSEIDON groups 3 and 4 patients require special attention as regards pre-treatment strategy, ovarian stimulation, adjuvant treatment, and ovulation trigger strategy in order to optimize the probability of having at least one euploid blastocyst for transfer.
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A new possibility in fertility preservation: The artificial ovary
TL;DR: A deeper understanding of mechanical and biochemical properties of the ovary and folliculogenesis after cryopreservation, transplantation with or without scaffold, and development of sophisticated in vivo imaging techniques of transplanted artificial ovary need to precede its efficient clinical application.
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Novel Physiology and Definition of Poor Ovarian Response; Clinical Recommendations.
TL;DR: The impact of the POSEIDON classification on the clinical management of patients with POR is discussed, which significantly reduces the heterogeneity of the Bologna criteria definition of POR and helps in the clinical handling and counseling of patients.
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Oocyte cryopreservation review: outcomes of medical oocyte cryopreservation and planned oocyte cryopreservation
TL;DR: In this paper , the authors provide a narrative review of the most recent and robust data on the utilization and outcomes of oocyte cryopreservation (OC) in both patient populations and show that OC results in similar oocyte yield in patients facing gonadotoxic therapies and patients undergoing planned OC.
References
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Fertility Preservation for Patients With Cancer: American Society of Clinical Oncology Clinical Practice Guideline Update
Alison W. Loren,Pamela B. Mangu,Lindsay Nohr Beck,Lawrence V. Brennan,Anthony J. Magdalinski,Ann H. Partridge,Gwendolyn P. Quinn,W. Hamish B. Wallace,Kutluk Oktay,Anthony J. Magda,Nohr Beck +10 more
TL;DR: Health care providers should address the possibility of infertility with patients treated during their reproductive years and be prepared to discuss fertility preservation options and/or to refer all potential patients to appropriate reproductive specialists.
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EGF-like growth factors as mediators of LH action in the ovulatory follicle.
TL;DR: It is demonstrated that LH stimulation induces the transient and sequential expression of the epidermal growth factor (EGF) family members amphiregulin, epire gulin, and beta-cellulin, which are paracrine mediators that propagate the LH signal throughout the follicle.
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Highly efficient vitrification for cryopreservation of human oocytes and embryos: the cryotop method
TL;DR: A modification of the technique using a hermetically sealed container for storage may help to eliminate potential dangers of disease transmission and open the way for widespread application for cryopreservation at all phases of oocyte and preimplantation embryo development in mammals.
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Web-based survey of fertility issues in Young women with breast cancer
Ann H. Partridge,Shari Gelber,Jeffrey Peppercorn,Ebonie Sampson,Katherine Knudsen,Marc R. Laufer,R. Rosenberg,M. Przypyszny,Alison Rein,Eric P. Winer +9 more
TL;DR: Fertility after treatment is a major concern for young women with breast cancer and there is a need to communicate with and educate young patients regarding fertility issues at diagnosis and a need for future research directed at preserving fertility for young breast cancer survivors.
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Safety of Fertility Preservation by Ovarian Stimulation With Letrozole and Gonadotropins in Patients With Breast Cancer: A Prospective Controlled Study
TL;DR: Ovarian stimulation with gonadotropins and letrozole for the purpose of fertility preservation is unlikely to cause substantially increased recurrence risk, and longer-term follow-up is needed to confirm these findings.