Good Stress, Bad Stress and Oxidative Stress: Insights from Anticipatory Cortisol Reactivity
Kirstin Aschbacher,Aoife O'Donovan,Aoife O'Donovan,Owen M. Wolkowitz,Firdaus S. Dhabhar,Yali Su,Elissa S. Epel +6 more
TLDR
This study supports the emerging model that chronic stress exposure promotes oxidative damage through frequent and sustained activation of the hypothalamic-pituitary-adrenal axis and supports the less studied model of 'eustress' - that manageable levels of life stress may enhance psychobiological resilience to oxidative damage.About:
This article is published in Psychoneuroendocrinology.The article was published on 2013-09-01 and is currently open access. It has received 342 citations till now. The article focuses on the topics: Chronic stress & Oxidative stress.read more
Citations
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Reactive oxygen species (ROS) as pleiotropic physiological signalling agents.
Helmut Sies,Dean P. Jones +1 more
TL;DR: This work focuses on ROS at physiological levels and their central role in redox signalling via different post-translational modifications, denoted as ‘oxidative eustress’.
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Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: Oxidative eustress.
TL;DR: The present overview focuses on recent progress on metabolic sources and sinks of H 2O2 and on the role of H2O2 in redox signaling under physiological conditions, denoted as oxidative eustress.
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Mitochondrial allostatic load puts the 'gluc' back in glucocorticoids.
TL;DR: It is proposed that mitochondrial dysfunction constitutes an early, modifiable target of chronic stress and stress-related health behaviours and the concept of 'mitochondrial allostatic load' defines the deleterious structural and functional changes that mitochondria undergo in response to elevated glucose levels and Stress-related pathophysiology.
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Physical Resilience in Older Adults: Systematic Review and Development of an Emerging Construct
Heather E. Whitson,Wei Duan-Porter,Kenneth E. Schmader,Miriam C. Morey,Harvey J. Cohen,Cathleen S. Colón-Emeric +5 more
TL;DR: A working definition of physical resilience at the whole person level is proposed: a characteristic which determines one's ability to resist or recover from functional decline following health stressor(s), which encompasses the related construct of physiologic reserve.
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Chronic stress as a risk factor for Alzheimer's disease: Roles of microglia-mediated synaptic remodeling, inflammation, and oxidative stress.
TL;DR: The interactions between chronic stress and AD pathology are discussed, the roles played by microglia are overviewed, especially focusing on chronic stress as an environmental risk factor modulating their function, and recently-described microglial phenotypes associated with neuroprotection in AD are presented.
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