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Open AccessJournal ArticleDOI

Guidelines for the Selection of Anti-infective Agents for Complicated Intra-abdominal Infections

TLDR
This work presents a meta-analysis of 125 cases of Clostridium difficile infection in mice over a 12-month period and shows clear patterns of disease progression that are consistent with tick-borne disease and suggest fungal infection.
Abstract
Joseph S. Solomkin, John E. Mazuski, Ellen J. Baron, Robert G. Sawyer, Avery B. Nathens, Joseph T. DiPiro, Timothy Buchman, E. Patchen Dellinger, John Jernigan, Sherwood Gorbach, Anthony W. Chow, and John Bartlett Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio; Department of Surgery, Washington University School of Medicine, St. Louis, Missouri; Department of Microbiology, Stanford University School of Medicine, Palo Alto, California; Department of Surgery, University of Virginia, Charlottesville; Department of Surgery, University of Washington, Seattle; University of Georgia College of Pharmacy, Department of Surgery, Medical College of Georgia, Augusta, and Centers for Disease Control and Prevention, Atlanta; Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland; and Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada

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The international sepsis forum consensus conference on definitions of infection in the intensive care unit.

TL;DR: Consensus definitions of infection were developed for the six most frequent causes of infections in septic patients: pneumonia, bloodstream infections (including infective endocarditis), intravascular catheter-related sepsis, intra-abdominal infections, urosepsi, and surgical wound infections.
Journal ArticleDOI

Diagnosis and management of complicated intra-abdominal infection in adults and children: guidelines by the Surgical Infection Society and the Infectious Diseases Society of America.

TL;DR: These updated guidelines replace those previously published in 2002 and 2003 and add recommendations for managing intra-abdominal infection in children, particularly where such management differs from that of adults; for appendicitis in patients of all ages; and for necrotizing enterocolitis in neonates.
References
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Journal ArticleDOI

Emergence of Antibiotic-Resistant Bacteria in Cases of Peritonitis After Intraabdominal Surgery Affects the Efficacy of Empirical Antimicrobial Therapy

TL;DR: The outcome of postoperative peritonitis is affected by the choice and adequacy of the initial empirical antibiotic therapy, and late changes in antibiotic therapy based on culture results did not affect outcome when the initial regimen was inadequate.
Journal ArticleDOI

Guide to development of practice guidelines.

TL;DR: A commonly accepted definition of a clinical practice guideline is "a systematically developed statement to assist practitioner and patient decisions about appropriate health care for specific clinical circumstances" as mentioned in this paper, which is not to create standards of care; however, other organizations may choose to adopt these guidelines or components thereof for such purposes.
Journal ArticleDOI

Antibiotic treatment for surgical peritonitis.

TL;DR: Patients treated with a single broad-spectrum antibiotic had a better outcome than patients treated with multiple drug treatment and inadequate empiric antibiotic treatment was associated with poorer outcome than any other type of treatment.
Journal ArticleDOI

Guidelines for clinical care: anti-infective agents for intra-abdominal infection. A Surgical Infection Society policy statement.

TL;DR: Guidelines have been developed for selection of antibiotic therapy for intra-abdominal infections and are presented as a statement of the Surgical Infection Society endorsed by the Executive Council.
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