Gut Microbiota Manipulation to Mitigate the Detrimental Effects of Environmental Pollutants
TLDR
The ecotoxicology and human health risks of environmental pollutants are creating global concern, especially in the context of the prevalent and severe contamination of environmental abiotic and biotic compartments as discussed by the authors.Abstract:
The ecotoxicology and human health risks of environmental pollutants are creating global concern, especially in the context of the prevalent and severe contamination of environmental abiotic and biotic compartments [...].read more
Citations
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Journal ArticleDOI
Fecal transplantation from young zebrafish donors efficiently ameliorates the lipid metabolism disorder of aged recipients exposed to perfluorobutanesulfonate.
TL;DR: Zhang et al. as mentioned in this paper transplanted the feces from young zebrafish donors to aged recipients, which were concurrently exposed to perfluorobutanesulfonate (PFBS), an emerging environmental pollutant of international concern.
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Probiotic supplementation mitigates the developmental toxicity of perfluorobutanesulfonate in zebrafish larvae.
TL;DR: Zhang et al. as discussed by the authors found that PFBS exposure significantly decreased larval body weight, weight gain and specific growth rate, while probiotic supplementation efficiently inhibited the growth retardation caused by PFBS, and probiotic combinations remarkably activated the antioxidant capacity to timely scavenge the reactive oxidative species and protect the larvae from lipid peroxidation.
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Probiotics inhibit the stunted growth defect of perfluorobutanesulfonate via stress and thyroid axes in zebrafish larvae
TL;DR: In this article, probiotic supplements are able to mitigate the toxicity of perfluorobutanesulfonate (PFBS) in aquatic environments and potently disrupts the early developmental trajectory of teleosts.
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Disturbed glucose metabolism by perfluorobutanesulfonate pollutant and benefit of young fecal transplantation in aged zebrafish.
TL;DR: In this paper , the effects of young fecal transplant on the metabolic pathways of glucose and glycogen, involving glycolysis, gluconeogenesis, glycogenesis, and glyogenolysis, were explored along the gut-liver axis.
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Metabolomic profiles in zebrafish larvae following probiotic and perfluorobutanesulfonate coexposure
TL;DR: In this article , the combined effects of PFBS and probiotics on metabolic dynamics, based on which gene transcriptions, enzymatic activities, and behavioral endpoints were further examined, showed that probiotic supplements were the major driver of the metabolomic fingerprints in coexposed zebrafish larvae.
References
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Journal ArticleDOI
Oral Administration of Probiotics Inhibits Absorption of the Heavy Metal Cadmium by Protecting the Intestinal Barrier
Qixiao Zhai,Qixiao Zhai,Fengwei Tian,Fengwei Tian,Jianxin Zhao,Hao Zhang,Hao Zhang,Arjan Narbad,Wei Chen,Wei Chen,Wei Chen +10 more
TL;DR: Along with initial intestinal Cd sequestration, probiotics can inhibit Cd absorption by protecting the intestinal barrier, and the protection is related to the alleviation of Cd-induced oxidative stress.
Journal ArticleDOI
Lactobacillus plantarum TW1-1 Alleviates Diethylhexylphthalate-Induced Testicular Damage in Mice by Modulating Gut Microbiota and Decreasing Inflammation
Xiaozhu Tian,Zhengsheng Yu,Pengya Feng,Ze Ye,Rong Li,Juyuan Liu,Junping Hu,Apurva Kakade,Pu Liu,Xiangkai Li +9 more
TL;DR: Oral supplementation of L. plantarum TW1-1 prevents DEHP-induced testicular damage via modulating gut microbiota and decreasing inflammation and correlation analysis showed that the Firm/Bac ratio was negatively correlated with testicularDamage and inflammation.
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Probiotic Modulation of Lipid Metabolism Disorders Caused by Perfluorobutanesulfonate Pollution in Zebrafish.
TL;DR: In female fish, the PFBS and probiotic combination enhanced fatty acid synthesis and β-oxidation, but mitigated the accumulation of cholesterol in the blood compared with PFBS single exposure, highlighting the benefits of the probiotic to host health.
Journal ArticleDOI
Impaired Intestinal Akkermansia muciniphila and Aryl Hydrocarbon Receptor Ligands Contribute to Nonalcoholic Fatty Liver Disease in Mice.
Zunji Shi,Zunji Shi,Hehua Lei,Gui Chen,Peihong Yuan,Zheng Cao,Hooi-Leng Ser,Xuehang Zhu,Fang Wu,Caixiang Liu,Manyuan Dong,Yuchen Song,Yangyang Guo,Chuan Chen,Kexin Hu,Yifan Zhu,Xin An Zeng,Jinlin Zhou,Yu-Jing Lu,Andrew D. Patterson,Limin Zhang +20 more
TL;DR: In this article, the authors identify a mechanism linking intestinal Akkermansia muciniphila and the aryl hydrocarbon receptor (AHR) to saccharin/sucralose-induced nonalcoholic fatty liver disease (NAFLD) in mice.
Journal ArticleDOI
Prebiotic inulin consumption reduces dioxin-like PCB 126-mediated hepatotoxicity and gut dysbiosis in hyperlipidemic Ldlr deficient mice.
Jessie B. Hoffman,Michael C. Petriello,Michael C. Petriello,Andrew J. Morris,Andrew J. Morris,M. Abdul Mottaleb,M. Abdul Mottaleb,Yipeng Sui,Changcheng Zhou,Pan Deng,Chunyan Wang,Bernhard Hennig +11 more
TL;DR: The hypothesis that a dietary intervention that targets the gut microbiota may be an effective means of attenuating dioxin-like pollutant-mediated diseases is supported.