Gut Microbiota Metabolites of Dietary Lignans and Risk of Type 2 Diabetes: A Prospective Investigation in Two Cohorts of U.S. Women
Qi Sun,Qi Sun,Nicole M. Wedick,An Pan,Mary K. Townsend,Aedin Cassidy,Adrian A. Franke,Eric B. Rimm,Eric B. Rimm,Frank B. Hu,Frank B. Hu,Rob M. van Dam,Rob M. van Dam +12 more
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TLDR
Results indicate that lignan metabolites, especially enterolactone, are associated with a lower risk of T2D in U.S. women.Abstract:
In both cohorts, T2D subjects had significantly lower concentrations of both enterolactone and enterodiol than control subjects. After multivariate adjustment for lifestyle and dietary risk factors of T2D, urinary concentrations of enterolactone were significantly associated with a lower risk of T2D (pooled odds ratio [OR] comparing the extreme quartiles 0.62 [95% CI 0.44, 0.88], P for trend = 0.003). Higher urinary concentrations of enterodiol were also marginally significantly associated with a lower T2D risk (pooled OR comparing extreme quartiles 0.67 [95% CI 0.48, 0.96], P for trend = 0.08). When concentrations of both metabolites were combined to reflect total lignan intake, the OR was 0.70 (95% CI 0.53, 0.92) for each SD increment of total lignan metabolites. CONCLUSIONSread more
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