Journal ArticleDOI
Hemodynamic analysis of a curved artery based on microcirculation boundary.
TLDR
This work is useful for researchers to deeply understand the hemodynamic characteristics of curved arteries and there is important clinical significance to analyze the pathogenesis of cardiovascular disease considering microcirculation function and its coupling effect.Abstract:
BACKGROUND
Microcirculation plays a key role in regulating blood flow but is not considered in previous research of hemodynamics.
OBJECTIVE
A curved artery model is established to study its hemodynamic characteristics based on microcirculation boundary.
METHODS
The hemodynamic model of a curved artery is constructed and simulated by computational fluid dynamics. The curved artery model is simulated by fluid-structure interaction. At the same time, a porous medium is used to simulate microcirculation as the outlet boundary.
RESULTS
The distribution characteristics of the blood flow velocity, the pressure and the wall shear stress in different sections at different time of the cardiac cycle are obtained. The results show that the velocities in curved arteries decrease and the pressures gradually increase. The blood flow velocity waveform and value are affected and they are sensitive to the microcirculation boundary. However, the pressure value is only affected by the microcirculation function.
CONCLUSIONS
This work is useful for researchers to deeply understand the hemodynamic characteristics of curved arteries. There is important clinical significance to analyze the pathogenesis of cardiovascular disease considering microcirculation function and its coupling effect.read more
References
More filters
Journal ArticleDOI
Role of endothelial shear stress in the natural history of coronary atherosclerosis and vascular remodeling: molecular, cellular, and vascular behavior.
Yiannis S. Chatzizisis,Ahmet U. Coskun,Michael Jonas,Elazer R. Edelman,Elazer R. Edelman,Charles L. Feldman,Peter Stone +6 more
TL;DR: The molecular, cellular, and vascular processes supporting the role of low ESS in the natural history of coronary atherosclerosis and vascular remodeling are explored and likely mechanisms concerning the different natural history trajectories of individual coronary lesions are indicated.
Journal ArticleDOI
Pulse pressure—a review of mechanisms and clinical relevance
TL;DR: The origin, clinical relevance and treatment of pulse pressure is reviewed, and a distributed compliance model of the arterial circulation provides a framework for understanding the causes, effects and potential treatment of elevations in PP.
Journal ArticleDOI
Pulse Wave Propagation in the Arterial Tree
TL;DR: The beating heart creates blood pressure and flow pulsations that propagate as waves through the arterial tree that are reflected at transitions in arterial geometry and elasticity, and these waves carry information about the matter in which they propagate.
Journal ArticleDOI
Blood flow analysis of the aortic arch using computational fluid dynamics.
Satoshi Numata,Keiichi Itatani,Keiichi Kanda,Kiyoshi Doi,Sachiko Yamazaki,Kazuki Morimoto,Kaichiro Manabe,Koki Ikemoto,Hitoshi Yaku +8 more
TL;DR: The high OSI site was similar to the favourite entry site for acute aortic dissection, indicating the causal relationship between mechanical stress and acute aortal dissection.
Related Papers (5)
Numerical modeling in arterial hemodynamics incorporating fluid-structure interaction and microcirculation
Fan He,Lu Hua,Tingting Guo +2 more