Journal ArticleDOI
Hepatocellular carcinoma in Italian patients with cirrhosis.
Massimo Colombo,de Franchis R,Del Ninno E,Angelo Sangiovanni,De Fazio C,M. A. Tommasini,Maria Francesca Donato,Anna Piva,Di Carlo,Nicola Dioguardi +9 more
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TLDR
In the West, as in Asia, patients with cirrhosis of the liver are at substantial risk for hepatocellular carcinoma, with a yearly incidence rate of 3 percent, and the screening program did not appreciably increase the rate of detection of potentially curable tumors.Abstract:
Background and Methods. Patients with cirrhosis of the liver are recognized as being at risk for hepatocellular carcinoma. The magnitude of the risk, the natural history of this disease, and the possibilities for detecting potentially curable tumors in patients in the Western world are unknown. To address these questions, we examined 447 Italian patients with well-compensated cirrhosis (which was of viral origin in 62 percent of them) from 1985 through 1990, performing serum alpha-fetoprotein assays and real-time ultrasonography every 3 to 12 months. Results. Hepatocellular carcinoma was found in 30 patients (7 percent) at base line and in another 29 patients (7 percent of 417 patients free of tumor at base line) during follow-up periods averaging 33 months (range, 1 to 48). The cumulative hazard of the development of hepatocellular carcinoma during follow-up was higher among patients with persistently elevated serum alpha-fetoprotein levels (12 with tumors among 42 with such levels) than among t...read more
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AASLD PRACTICE GUIDELINE Management of Hepatocellular Carcinoma: An Update
Jordi Bruix,Morris Sherman +1 more
TL;DR: Since the publication of the American Association for the Study of Liver Diseases (AASLD) practice guidelines on the management of hepatocellular carcinoma (HCC) in 2005, new information has emerged that requires that the guidelines be updated.
Journal ArticleDOI
Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis
Vincenzo Mazzaferro,Enrico Regalia,Roberto Doci,Salvatore Andreola,A. Pulvirenti,Federico Bozzetti,F. Montalto,Mario Ammatuna,Alberto Morabito,Leandro Gennari +9 more
TL;DR: Liver transplantation is an effective treatment for small, unresectable hepatocellular carcinomas in patients with cirrhosis and after four years, the actuarial survival rate was 75 percent and the rate of recurrence-free survival was 83 percent.
Journal ArticleDOI
Management of hepatocellular carcinoma.
Jordi Bruix,Morris Sherman +1 more
TL;DR: The prevention of Cirrhosis can prevent the development of HCC and progression from chronic HCV infection to advanced fibrosis or cirrhosis may be prevented in 40% of patients who are sustained responders to new antiviral strategies, such as pegylated interferon and ribavirin.
Journal ArticleDOI
Clinical Management of Hepatocellular Carcinoma. Conclusions of the Barcelona-2000 EASL Conference
Jordi Bruix,Morris Sherman,Josep M. Llovet,Michel Beaugrand,Riccardo Lencioni,Andrew K. Burroughs,Erik Christensen,Luigi Pagliaro,Massimo Colombo,Juan Rodés +9 more
Journal ArticleDOI
Hepatitis C Virus Infection
Georg M. Lauer,Bruce D. Walker +1 more
TL;DR: The institution of blood-screening measures in developed countries has decreased the risk of transfusion-associated hepatitis to a negligible level, but new cases continue to occur mainly as a result of injection-drug use and, to a lesser degree, through other means of percutaneous or mucous-membrane exposure.
References
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Transection of the oesophagus for bleeding oesophageal varices
TL;DR: Emergency ligation of bleeding oesophageal varices using the Milnes Walker technique was performed in 38 patients, and in patients with good preoperative liver function this rose to 71% and the simple scoring system for grading the severity of disturbance of liver function was found to be of value in predicting the outcome of surgery.
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Maximum utilization of the life table method in analyzing survival
Sidney J. Cutler,Fred Ederer +1 more
TL;DR: Acceptance of survival as a criterion for measuring the effectiveness of cancer therapy is attested to by the very large number of papers published every year reporting on the survival experience of cancer patients.
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Detection of antibody to hepatitis C virus in prospectively followed transfusion recipients with acute and chronic non-A, non-B hepatitis
Harvey J. Alter,Robert H. Purcell,James Wai-Kuo Shih,Jacqueline C. Melpolder,Michael Houghton,Qui-Lim Choo,George Kuo +6 more
TL;DR: It is concluded that hepatitis C virus is the predominant agent of transfusion-associated non-A, non-B hepatitis and that screening of donors for anti-HCV could prevent the majority of cases of the disease.
Journal ArticleDOI
Prospective study of early detection of hepatocellular carcinoma in patients with cirrhosis.
Hiroko Oka,Narito Kurioka,Kosyun Kim,Toru Kanno,Tetsuo Kuroki,Yasuhiro Mizoguchi,Kenzo Kobayashi +6 more
TL;DR: periodic monitoring by use of ultrasonography in particular is recommended for early detection of hepatocellular carcinoma, especially patients with cirrhosis or with a history of blood transfusion who are negative for HBsAg.
Journal ArticleDOI
Natural history of minute hepatocellular carcinoma smaller than three centimeters complicating cirrhosis. A study in 22 patients.
Masaaki Ebara,Masao Ohto,Takashi Shinagawa,Nobuyuki Sugiura,Kunio Kimura,Shoichi Matsutani,Masahiko Morita,Hiromitsu Saisho,Yukihiro Tsuchiya,Kunio Okuda +9 more
TL;DR: Serum alpha-fetoprotein levels were generally low, rarely assisted in diagnosis, but tended to increase when the mass attained a diameter of greater than 3 cm; sudden acceleration in the rate of increase in alpha- Fetoprotein level often coincided with a change of ultrasonic pattern to the massive one.