Journal ArticleDOI
Hereditary factors in sleepwalking and night terrors.
Anthony Kales,Constantin R. Soldatos,Edward O. Bixler,Roger L. Ladda,Dennis S. Charney,Gary Weber,Paula K. Schweitzer +6 more
TLDR
The data appear to fit a 'two threshold' multifactorial mode of inheritance, which supports the hypothesis that sleepwalking and night terrors share a common genetic predisposition, with sleepwalking being a more prevalent and less severe manifestation of the same substrate that underliesNight terrors.Abstract:
The families of 25 probands with sleepwalking and 27 probands with night terrors were studied. Eighty per cent of the sleepwalking pedigrees and 96 per cent of the night terror pedigrees included one or more individuals, other than the proband, who were affected by sleepwalking, night terrors, or both. Our data appear to fit a 'two threshold' multifactorial mode of inheritance. This finding supports the hypothesis that sleepwalking and night terrors share a common genetic predisposition, with sleepwalking being a more prevalent and less severe manifestation of the same substrate that underlies night terrors. Heritable factors predispose an individual to develop sleepwalking and/or night terrors, but expression of the trait may be influenced by environmental factors.read more
Citations
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Classification of Sleep Disorders
TL;DR: The International Classification of Sleep Disorders, version 2, published in 2005 and currently undergoing revision, combines a symptomatic presentation with 1 organized in part on pathophysiology and in parton body systems to more easily differentiate between the disorders.
Journal ArticleDOI
Sleepwalking and Sleep Terrors in Prepubertal Children: What Triggers Them?
TL;DR: The clinical presentation and polysomnography of prepubertal children with repetitive sleep terrors and sleepwalking are evaluated, to compare them with a control group, and to evaluate the treatment of associated sleep disorders.
Journal ArticleDOI
REM sleep parasomnias.
TL;DR: The three states of mammalian being--wakefulness, REM sleep, and NREM sleep--are not mutually exclusive and may occur simultaneously, oscillate rapidly, or appear in dissociated or incomplete form to produce primary sleep parasomnias.
Journal ArticleDOI
Evidence for genetic influences on sleep disturbance and sleep pattern in twins.
TL;DR: There was no evidence for a decline in the importance of genetic predisposition with age and short-term environmental fluctuations accounted for as much as 30% of the variance, and more stable nonfamilial environmental effects accounted for the remainder.
Journal ArticleDOI
Autosomal dominant nocturnal frontal lobe epilepsy--a critical overview.
TL;DR: An overview on the clinical and genetic aspects of ADNFLE including a discussion of some open questions on the role of the neuronal nicotinic receptor subunit mutations in the pathogenesis of this form of epilepsy is discussed.
References
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Journal ArticleDOI
The inheritance of liability to certain diseases, estimated from the incidence among relatives
TL;DR: The purpose of this paper is to suggest that the method developed in quantitative genetics for dealing with ‘threshold characters ’ is applicable to data on the incidence of diseases, and that by its use the authors can get further towards an answer to the question of the relative importance of heredity and environment.
Book
Sleep and wakefulness
TL;DR: For half a century, "Sleep and Wakefulness" has been a valuable reference work as discussed by the authors It discusses phases of the sleep cycle, experimental work on sleep and wakefulness, sleep disorders and their treatment, and such sleep-like states as hypnosis and hibernation.
Journal ArticleDOI
Prevalence of sleep disorders in the Los Angeles metropolitan area.
TL;DR: Insomnia, nightmares, and hypersomnia were correlated with more frequent general physical and mental health problems and were often chronic and usually started early in life.
Journal ArticleDOI
Sleep Disorders: Disorders of Arousal?: Enuresis, somnambulism, and nightmares occur in confusional states of arousal, not in "dreaming sleep."
TL;DR: The classical sleep disorders of nocturnal enuresis, somnambulism, the nightmare, and the sleep terror occur preferentially during arousal from slow-wave sleep and are virtually never associated with the rapid-eye-movement dreaming state.