Heterogeneity of Glucose Transport in Lung Cancer
Cesar A. Martinez,Claudio Scafoglio +1 more
- Vol. 10, Iss: 6, pp 868
TLDR
An overview of different levels of heterogeneity in glucose uptake and utilization in lung cancer, with diagnostic and therapeutic implications is presented.Abstract:
Increased glucose uptake is a known hallmark of cancer. Cancer cells need glucose for energy production via glycolysis and the tricarboxylic acid cycle, and also to fuel the pentose phosphate pathway, the serine biosynthetic pathway, lipogenesis, and the hexosamine pathway. For this reason, glucose transport inhibition is an emerging new treatment for different malignancies, including lung cancer. However, studies both in animal models and in humans have shown high levels of heterogeneity in the utilization of glucose and other metabolites in cancer, unveiling a complexity that is difficult to target therapeutically. Here, we present an overview of different levels of heterogeneity in glucose uptake and utilization in lung cancer, with diagnostic and therapeutic implications.read more
Citations
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Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides
Richard Possemato,Franziska K. Lorbeer,Erol C. Bayraktar,Prathapan Thiru,Burcu Yucel,Timothy C. Wang,Walter W. Chen,Clary B. Clish,David M. Sabatini,Kıvanç Birsoy +9 more
TL;DR: A continuous-flow culture apparatus for maintaining proliferating cells in low-nutrient media for long periods of time is developed and used to undertake competitive proliferation assays, concluding that mtDNA mutations and impaired glucose utilization are potential biomarkers for identifying tumours with increased sensitivity to OXPHOS inhibitors.
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Anti-Warburg Effect of Melatonin: A Proposed Mechanism to Explain its Inhibition of Multiple Diseases.
TL;DR: In this paper, the authors proposed that melatonin's function as a glycolytic explains its actions in inhibiting a variety of diseases, such as the Warburg effect in solid tumors and in other pathological cells.
Journal ArticleDOI
Metabolic Regulation of Epigenetic Modifications and Cell Differentiation in Cancer.
Pasquale Saggese,Assunta Sellitto,Cesar A. Martinez,Giorgio Giurato,Giovanni Nassa,Francesca Rizzo,Roberta Tarallo,Claudio Scafoglio +7 more
TL;DR: A review of the literature on the interactions between metabolism and cell identity, and the mechanisms by which metabolic changes affect gene regulation are explored, with particular focus on the role of mitochondrial intermediates and hypoxia in the regulation of cellular de-differentiation.
Journal ArticleDOI
Harnessing chlorin e6 loaded by functionalized iron oxide nanoparticles linked with glucose for target photodynamic therapy and improving of the immunogenicity of lung cancer
Tingting Yu,Xingchun Peng,Mei Fang Wang,Ning Han,Hua-Zhen Xu,Qi-Rui Li,Liu-Gen Li,Xiang Xu,Qianli Ma,Bin Liu,Jue Wang,Li Zhao,Xiao Liang Chen,Tong Liu +13 more
TL;DR: Ce6 loaded by functionalized iron oxide nanoparticles linked with glucose exhibited both target photodynamic efficacy and the ability to enhance its immunogenicity in lung cancer.
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GLUT1 production in cancer cells: a tragedy of the commons
TL;DR: In this paper , a game theoretic model of glucose uptake based on a cell's investment in transporters relative to that of its neighboring cells is proposed. And the authors demonstrate a synergistic combination with standard-of-care therapies, while also displaying the existence of a tradeoff between competition among cancer cells and depression of their gain function.
References
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