Journal ArticleDOI
High serum IgG4 concentrations in patients with sclerosing pancreatitis.
Hideaki Hamano,Shigeyuki Kawa,Akira Horiuchi,Hiroshi Unno,Naoyuki Furuya,Taiji Akamatsu,Mana Fukushima,Toshio Nikaido,Kohzo Nakayama,Nobuteru Usuda,Kendo Kiyosawa +10 more
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TLDR
Patients with sclerosing pancreatitis have high serum IgG4 concentrations, providing a useful means of distinguishing this disorder from other diseases of the pancreas or biliary tract.Abstract:
Background Sclerosing pancreatitis is a unique form of pancreatitis that is characterized by irregular narrowing of the main pancreatic duct, lymphoplasmacytic inflammation of the pancreas, and hypergammaglobulinemia and that responds to glucocorticoid treatment. Preliminary studies suggested that serum IgG4 concentrations are elevated in this disease but not in other diseases of the pancreas or biliary tract. Methods We measured serum IgG4 concentrations using single radial immunodiffusion and an enzyme-linked immunosorbent assay in 20 patients with sclerosing pancreatitis, 20 age- and sex-matched normal subjects, and 154 patients with pancreatic cancer, ordinary chronic pancreatitis, primary biliary cirrhosis, primary sclerosing cholangitis, or Sjogren's syndrome. Serum concentrations of immune complexes and the IgG4 subclass of immune complexes were determined by means of an enzyme-linked immunosorbent assay with monoclonal rheumatoid factor. Results The median serum IgG4 concentration in the patients ...read more
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CT findings in autoimmune pancreatitis: assessment using multiphase contrast-enhanced multisection CT
TL;DR: The present study highlights pancreatic ductal enhancement in a subset of patients with autoimmune pancreatitis, which presented with a variety of CT findings in the pancreas and the extrapancreatic organs.
Journal ArticleDOI
Characteristics of immunoglobulin G4-related aortitis/periaortitis and periarteritis on fluorodeoxyglucose positron emission tomography/computed tomography co-registered with contrast-enhanced computed tomography
Satoshi Yabusaki,Noriko Oyama-Manabe,Osamu Manabe,Kenji Hirata,Fumi Kato,N Miyamoto,Yoshihiro Matsuno,Kohsuke Kudo,Nagara Tamaki,Hiroki Shirato +9 more
TL;DR: The entire aorta and major branches can be involved with more than 2-fold higher FDG uptake than the venous background pool, and with wall thickening, according to the image characteristics of IgG4-aortitis.
Journal ArticleDOI
Autoimmune Pancreatitis Associated with Various Extrapancreatic Lesions during a Long-term Clinical Course Successfully Treated with Azathioprine and Corticosteroid Maintenance Therapy
Itaru Naitoh,Takahiro Nakazawa,Hirotaka Ohara,Hitoshi Sano,Tomoaki Ando,Kazuki Hayashi,Hajime Tanaka,Fumihiro Okumura,Katsuyuki Miyabe,Michihiro Yoshida,Satoru Takahashi,Takashi Joh +11 more
TL;DR: A 62-year-old woman with AIP associated with various extrapancreatic lesions during a long-term clinical course found no relapse was observed for 5 years after the start of maintenance therapy with prednisolone and azathioprine.
Journal ArticleDOI
IgG4 cholangiopathy – Current concept, diagnosis, and pathogenesis
Kazuichi Okazaki,Kazushige Uchida,Masanori Koyabu,Hideaki Miyoshi,Tsukasa Ikeura,Makoto Takaoka +5 more
TL;DR: Although the precise pathogenic mechanism remains unclear, the development of IgG4-cholangiopathy may involve: susceptible genetic factors, abnormal innate and acquired immunity, decreased naïve regulatory T cells, and specific B cell responses.
Journal ArticleDOI
Pulmonary involvement of autoimmune pancreatitis.
Kenji Tsushima,Tsuyoshi Tanabe,H. Yamamoto,Tomonobu Koizumi,Shigeyuki Kawa,Hideaki Hamano,Takayuki Honda,Takeshi Uehara,Satoshi Kawakami,K. Kubo +9 more
TL;DR: The pulmonary involvement of autoimmune pancreatitis was analysed to clarify the clinicopathological features of pulmonary lesions in comparison with pulmonary sarcoidosis, and a wide variety of systemic lesions have been seen in patients with autoimmune Pancreatitis.
References
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Journal ArticleDOI
Chronic pancreatitis caused by an autoimmune abnormality : proposal of the concept of autoimmune pancreatitis
Kenji Yoshida,Fumitake Toki,Tadashi Takeuchi,Shin-ichiro Watanabe,Keiko Shiratori,Naoaki Hayashi +5 more
TL;DR: In this paper, the authors reported a case of chronic pancreatitis in which an autoimmune mechanism is involved in the etiology and summarized the cases of pancreatitis suspected of being caused by an auto-antibody-positive mechanism in the Japanese and English literature.
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