Journal ArticleDOI
High serum IgG4 concentrations in patients with sclerosing pancreatitis.
Hideaki Hamano,Shigeyuki Kawa,Akira Horiuchi,Hiroshi Unno,Naoyuki Furuya,Taiji Akamatsu,Mana Fukushima,Toshio Nikaido,Kohzo Nakayama,Nobuteru Usuda,Kendo Kiyosawa +10 more
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TLDR
Patients with sclerosing pancreatitis have high serum IgG4 concentrations, providing a useful means of distinguishing this disorder from other diseases of the pancreas or biliary tract.Abstract:
Background Sclerosing pancreatitis is a unique form of pancreatitis that is characterized by irregular narrowing of the main pancreatic duct, lymphoplasmacytic inflammation of the pancreas, and hypergammaglobulinemia and that responds to glucocorticoid treatment. Preliminary studies suggested that serum IgG4 concentrations are elevated in this disease but not in other diseases of the pancreas or biliary tract. Methods We measured serum IgG4 concentrations using single radial immunodiffusion and an enzyme-linked immunosorbent assay in 20 patients with sclerosing pancreatitis, 20 age- and sex-matched normal subjects, and 154 patients with pancreatic cancer, ordinary chronic pancreatitis, primary biliary cirrhosis, primary sclerosing cholangitis, or Sjogren's syndrome. Serum concentrations of immune complexes and the IgG4 subclass of immune complexes were determined by means of an enzyme-linked immunosorbent assay with monoclonal rheumatoid factor. Results The median serum IgG4 concentration in the patients ...read more
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Retroperitoneal disorders associated with IgG4-related autoimmune pancreatitis.
TL;DR: IgG4-related autoimmune pancreatitis is frequently accompanied by relevant lesions in the genitourinary tract and retroperitoneal organs, which cause various clinical problems, ranging from non-specific back pain or bladder outlet obstruction to renal failure.
Journal ArticleDOI
Conference Report: Korea-Japan Symposium on Autoimmune Pancreatitis
Seung Woo Park,Jae Bock Chung,Makoto Otsuki,Myung-Hwan Kim,Jae Hoon Lim,Shigeyuki Kawa,Tetsuhide Ito,Isao Nishimori,Ji Kon Ryu,Kazuichi Okazaki,Kyutaek Lee,Terumi Kamisawa +11 more
TL;DR: A consensus meeting on autoimmune pancreatitis was held in Seoul on August 31, 2007, and the need for unified diagnostic criterion for AIP in Korea and Japan was indicated.
Journal ArticleDOI
Autoimmune Pancreatitis - Diagnosis, Management and Longterm Follow-up
Suvadip Chatterjee,Kofi Oppong,J. Scott,Dave E Jones,Richard Charnley,Derek Manas,Byron C Jaques,Steve White,Jeremy French,Gourab Sen,B Haugk,Manu Nayar +11 more
TL;DR: Awareness of this relatively rare condition and a multi-disciplinary team approach will help to diagnose and treat this condition more effectively thereby reducing unnecessary interventions.
Journal ArticleDOI
IgG4-related cholecystitis presenting as biliary malignancy: report of three cases.
TL;DR: Recognition of the clinical, radiographic, and pathologic presentation of IgG4-related cholecystitis is essential for the consideration of this disease process prior to surgical management for suspected gallbladder malignancies.
Journal ArticleDOI
Localized or diffuse lesions of the submandibular glands in immunoglobulin g4-related disease in association with differential organ involvement.
Satomi Asai,Kenji Okami,Naoya Nakamura,Shuichi Shiraishi,Ryousuke Sugimoto,Damdinsuren Anar,Shinji Sato,Hiromichi Matsushita,Yasuo Suzuki,Hayato Miyachi +9 more
TL;DR: The distinctive patient groups defined by the sonographic patterns in both glands were associated with differential organ involvement and thus could be used as indicators of the disease extension and specific organ involvement.
References
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Journal ArticleDOI
Chronic pancreatitis caused by an autoimmune abnormality : proposal of the concept of autoimmune pancreatitis
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