Journal ArticleDOI
Highly functionalized organomagnesium reagents prepared through halogen-metal exchange.
Paul Knochel,Wolfgang Dohle,Nina Gommermann,Florian F. Kneisel,Felix Kopp,Tobias J. Korn,Ioannis Sapountzis,Viet Anh Vu +7 more
TLDR
Recently, the halogen-magnesium exchange has considerably extended the range of functionalized Grignard reagents available for synthetic purposes and new applications of organomagnesium reagents in cross-coupling reactions and amination reactions will be covered in this Review.Abstract:
Organomagnesium reagents occupy a central position in synthetic organic and organometallic chemistry. Recently, the halogen-magnesium exchange has considerably extended the range of functionalized Grignard reagents available for synthetic purposes. Functional groups such as esters, nitriles, iodides, imines, or even nitro groups can be present in a wide range of aromatic and heterocyclic organomagnesium reagents. Also various highly functionalized alkenyl magnesium species can be prepared. These recent developments as well as new applications of organomagnesium reagents in cross-coupling reactions and amination reactions will be covered in this Review.read more
Citations
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Advances in transition metal (Pd, Ni, Fe)-catalyzed cross-coupling reactions using alkyl-organometallics as reaction partners.
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Transition-Metal-Free Coupling Reactions
TL;DR: This research presents a new generation of state-of-the-art materials for bioorganic and non-volatile organometallic research that combines high-performance liquid chromatography and high-tech materials for organic synthesis.
Journal ArticleDOI
Catalytic asymmetric conjugate addition and allylic alkylation with Grignard reagents.
TL;DR: Achieving chemo-, regioand stereocontrol in both asymmetric conjugate addition (ACA) and asymmetric allylic alkylation (AAA), however, has proven to be challenging and has restricted the application of these transformations, in particular, to total synthesis.
Journal ArticleDOI
Engaging unactivated alkyl, alkenyl and aryl iodides in visible-light-mediated free radical reactions
TL;DR: Visible-light-mediated photocatalytic generation of carbon-centred radicals from alkyl, alkenyl and aryl iodides, which then undergo subsequent hydrogen-atom abstraction or reductive cyclizations, is reported.
Journal ArticleDOI
Metal-catalyzed activation of ethers via C–O bond cleavage: a new strategy for molecular diversity
TL;DR: This review summarizes the most significant developments in the area of C-O bond-cleavage when employing aryl or vinyl ethers, providing a detailed overview of the current state of the art and including future aspects, when applicable.
References
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Directed ortho metalation. Tertiary amide and O-carbamate directors in synthetic strategies for polysubstituted aromatics
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Rational Development of Practical Catalysts for Aromatic Carbon−Nitrogen Bond Formation
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Transition Metal Catalyzed Synthesis of Arylamines and Aryl Ethers from Aryl Halides and Triflates: Scope and Mechanism.
TL;DR: Oxidative addition and reductive elimination are the central steps in new palladium-catalyzed chemistry that forms C-N and C-O bonds in arylamines and ethers.
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