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Histologic and ultrastructural features of the clara cell adenoma of the mouse lung.
S L Kauffman,L Alexander,L Sass +2 more
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This article is published in Laboratory Investigation.The article was published on 1979-06-01 and is currently open access. It has received 146 citations till now.read more
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Classification of Proliferative Pulmonary Lesions of the Mouse: Recommendations of the Mouse Models of Human Cancers Consortium
Alexander Yu. Nikitin,Ana Alcaraz,Miriam R. Anver,Roderick T. Bronson,Robert D. Cardiff,Darlene Dixon,Armando E. Fraire,Edward Gabrielson,William T. Gunning,Diana C. Haines,Matthew H. Kaufman,R. Ilona Linnoila,Robert R. Maronpot,Alan S. Rabson,Robert L. Reddick,Sabine Rehm,Nora Rozengurt,Hildegard M. Schuller,Elena N. Shmidt,William D. Travis,Jerrold M. Ward,Tyler Jacks +21 more
TL;DR: A series of discussions was initiated by a panel of human, veterinary, and experimental pathologists during the Mouse Models of Human Cancers Consortium (NIH/National Cancer Institute) workshop on mouse models of lung cancer, and a new practical classification scheme was recommended that would allow easier comparison between human and mouse lung neoplasms.
Journal Article
Relationship between the Formation of Promutagenic Adducts and the Activation of the K-ras Protooncogene in Lung Tumors from A/J Mice Treated with Nitrosamines
Steven A. Belinsky,Theodora R. Devereux,Robert R. Maronpot,Gary D. Stoner,Marshall W. Anderson +4 more
TL;DR: Southern blot analysis indicated that the transforming gene present in all lung tumors was an activated K-ras oncogene, and this gene appeared to occur largely via a mutation in codon 12 and was observed with a similar frequency in pulmonary tumors induced by either NNK or NDMA.
Journal ArticleDOI
The effects of dietary butylated hydroxytoluene on liver and colon tumor development in mice
TL;DR: It is concluded that the effect of BHT on tumor development depends on strain and target organ examined and possibly also on the chemical carcinogen used.
Journal Article
Role of the alveolar type II cell in the development and progression of pulmonary tumors induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in the A/J mouse.
Steven A. Belinsky,Theodora R. Devereux,Julie F. Foley,Robert R. Maronpot,Marshall W. Anderson +4 more
TL;DR: The role of the type II cell in the development of pulmonary tumors induced in the adult A/J mouse (6 weeks of age) by treatment with a single dose (100 mg/kg, i.p.) of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) was investigated as mentioned in this paper.
Journal ArticleDOI
The genetic basis of susceptibility to lung tumors in mice.
TL;DR: The mouse lung tumorigenesis system is valuable as a biological model for studying stages of tumor development and the interaction of genetic and environmental factors which dispose towards neoplasia.