Journal ArticleDOI
Histological Substrate of Atrial Biopsies in Patients With Lone Atrial Fibrillation
Andrea Frustaci,Cristina Chimenti,Fulvio Bellocci,Emanuela Morgante,Matteo A. Russo,Attilio Maseri +5 more
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TLDR
Abnormal atrial histology was uniformly found in multiple biopsy specimens in all patients with LAF and was compatible with a diagnosis of myocarditis in 66% of patients and of noninflammatory localized cardiomyopathy in 17% and was represented by patchy fibrosis in 17%.Abstract:
Background Lone atrial fibrillation (LAF) is a common clinical syndrome, but its origin remains unknown. Methods and Results We performed endomyocardial biopsies of the right atrial septum (2 to 3 per patient; mean, 2.8) and of the two ventricles (6 per patient) in 12 patients (10 men, 2 women; mean age, 32 years) with paroxysmal LAF refractory to conventional antiarrhythmic treatment. As controls, we used endomyocardial biopsies (3 to 5 per patient; mean, 4.4) from the right atrial septum of 11 patients with Wolff-Parkinson-White syndrome (WPW) undergoing resection of the abnormal AV pathway. The weight of the biopsies ranged from 2.8 to 4.5 mg. Biopsy samples were processed for histology and electron microscopy and were read by a pathologist blinded to clinical data. All patients underwent two-dimensional Doppler echocardiography; cardiac catheterization; coronary angiography; and hormonal, virologic, and electrophysiological studies. All tests and WPW biopsies were normal, but all LAF atrial biopsy spe...read more
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Journal ArticleDOI
Endotoxemia, inflammation, and atrial fibrillation.
TL;DR: Experimental LPS challenge led to a significant increase in acute inflammatory indexes, but did not increase the propensity to new-onset AF in a young low-risk population.
Journal ArticleDOI
Polymorphisms of the angiotensin-converting enzyme and angiotensinogen gene in patients with atrial fibrillation
Nurdan Papila Topal,Beste Ozben,Veysel Sabri Hancer,Azra Meryem Tanrikulu,Reyhan Diz-Kucukkaya,Ali Serdar Fak,Yelda Basaran,Osman Yesildag +7 more
TL;DR: Investigation of the relation between AF and polymorphisms in RAS found patients with AF had significantly larger left atrium, higher left ventricular mass index (LVMI) and higher frequency of significant valvular pathology, while patients with a specific genetic variation in the RAS genes may be more liable to develop AF.
Journal ArticleDOI
Lack of effect of statins on maintenance of normal sinus rhythm following electrical cardioversion of persistent atrial fibrillation.
TL;DR: Current evidence does not suggest that statins are associated with an increased probability of maintaining NSR following ECV of persistent AF, and pooled estimates of effect are reported as relative risks (RRs) with accompanying 95% confidence intervals (CIs) using a random‐effects model.
Journal ArticleDOI
Association between serum C-reactive protein elevation and atrial fibrillation after first anterior myocardial infarction.
Omer Gedikli,Cihan Örem,Merih Baykan,Caner Karahan,Mehmet Küçükosmanoglu,Sinan Şahin,Levent Korkmaz,Hulya Yilmaz,Şükrü Çelik +8 more
TL;DR: This study investigated whether CRP is a risk factor for AF in patients with acute anterior MI and found that it is not.
Journal ArticleDOI
Atrial remodelling and function: implications for atrial fibrillation surgery.
Stefano Benussi,Gijs E. De Maat +1 more
TL;DR: The pathophysiological aspects of AF related to left atrial function and their practical implications for surgical rhythm management are highlighted and surgical and hybrid ablation show very promising results.
References
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Journal ArticleDOI
Right Ventricular Cardiomyopathy and Sudden Death in Young People
TL;DR: Findings indicate that right ventricular cardiomyopathy, the cause of which is still unknown, may be more frequent than previously thought and may represent an important cause of sudden death among young people in the Veneto Region of northeastern Italy.
Journal Article
Myocarditis. A histopathologic definition and classification.
HT Aretz,ME Billingham,William D. Edwards,SM Factor,John T. Fallon,Jr Jj Fenoglio,E. G. J. Olsen,Frederick J. Schoen +7 more
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Chronic Rapid Atrial Pacing Structural, Functional, and Electrophysiological Characteristics of a New Model of Sustained Atrial Fibrillation
TL;DR: In this article, two-dimensional echocardiography was performed in 11 dogs to assess the effects of rapid atrial pacing on atrial size, which was defined as the ability to induce sustained repetitive atrial responses during programmed electrical stimulation and was assessed by extrastimulus and burst-pacing techniqu...
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The natural history of lone atrial fibrillation. A population-based study over three decades.
Stephen L. Kopecky,Bernard J. Gersh,Michael D. McGoon,Jack P. Whisnant,David R. Holmes,Duane M. Ilstrup,Robert L. Frye +6 more
TL;DR: It is concluded that lone atrial fibrillation in patients under the age of 60 at diagnosis is associated with a very low risk of stroke, and routine anticoagulation may not be warranted.
Journal ArticleDOI
Characteristics and Prognosis of Lone Atrial Fibrillation: 30-Year Follow-up in the Framingham Study
TL;DR: It is suggested that subjects with lone AF, despite similar cardiovascular risk profiles to normal controls, have a distinct preponderance of preexisting electrocardiographic abnormalities.