Journal ArticleDOI
Histological Substrate of Atrial Biopsies in Patients With Lone Atrial Fibrillation
Andrea Frustaci,Cristina Chimenti,Fulvio Bellocci,Emanuela Morgante,Matteo A. Russo,Attilio Maseri +5 more
Reads0
Chats0
TLDR
Abnormal atrial histology was uniformly found in multiple biopsy specimens in all patients with LAF and was compatible with a diagnosis of myocarditis in 66% of patients and of noninflammatory localized cardiomyopathy in 17% and was represented by patchy fibrosis in 17%.Abstract:
Background Lone atrial fibrillation (LAF) is a common clinical syndrome, but its origin remains unknown. Methods and Results We performed endomyocardial biopsies of the right atrial septum (2 to 3 per patient; mean, 2.8) and of the two ventricles (6 per patient) in 12 patients (10 men, 2 women; mean age, 32 years) with paroxysmal LAF refractory to conventional antiarrhythmic treatment. As controls, we used endomyocardial biopsies (3 to 5 per patient; mean, 4.4) from the right atrial septum of 11 patients with Wolff-Parkinson-White syndrome (WPW) undergoing resection of the abnormal AV pathway. The weight of the biopsies ranged from 2.8 to 4.5 mg. Biopsy samples were processed for histology and electron microscopy and were read by a pathologist blinded to clinical data. All patients underwent two-dimensional Doppler echocardiography; cardiac catheterization; coronary angiography; and hormonal, virologic, and electrophysiological studies. All tests and WPW biopsies were normal, but all LAF atrial biopsy spe...read more
Citations
More filters
Journal ArticleDOI
Aortic Stiffness in Lone Atrial Fibrillation: A Novel Risk Factor for Arrhythmia Recurrence
Dennis H. Lau,Melissa E. Middeldorp,Anthony G. Brooks,Anand N. Ganesan,Kurt C. Roberts-Thomson,Martin K. Stiles,Darryl P. Leong,Hany S. Abed,Han S. Lim,Christopher X. Wong,Scott R. Willoughby,Glenn D. Young,Jonathan M. Kalman,Walter P. Abhayaratna,Prashanthan Sanders +14 more
TL;DR: Aortic stiffness is an important risk factor in patients with lone atrial fibrillation and contributes to higher atrialfibrillation recurrence following catheter ablation procedure, according to Kaplan-Meier analysis.
Journal ArticleDOI
Fibrinogen and albumin levels and risk of atrial fibrillation in men and women (the Copenhagen City Heart Study).
TL;DR: Higher levels of fibrinogen and lower levels of albumin were prospectively associated with a higher risk of AF, even accounting for their relation with the risk of cardiovascular disease.
Journal ArticleDOI
Role of Angiotensin‐Converting Enzyme Inhibitors, Angiotensin II Receptor Blockers, and Aldosterone Antagonists in the Prevention of Atrial and Ventricular Arrhythmias
TL;DR: Results of post hoc analyses from prospective clinical trials appear to show that angiotensin‐converting enzyme (ACE) inhibitors and angiotENSin II receptor blockers (ARBs) are most effective in the prevention of new‐onset atrial fibrillation in patients with heart failure.
Journal ArticleDOI
Expression and activity of ectopeptidases in fibrillating human atria.
Uwe Lendeckel,Marco Arndt,Sabine Wrenger,Karen Nepple,Christof Huth,Siegfried Ansorge,Helmut U. Klein,Andreas Goette +7 more
TL;DR: Atrial bradykinin metabolizing activities are significantly altered during AF in humans, and the observed alterations in ectopeptidase expression/activity may play a role in the structural remodeling of fibrillating atria.
Journal ArticleDOI
Effects of statin therapy on preventing atrial fibrillation in coronary disease and heart failure.
TL;DR: It is hypothesized that statin use will reduce incident atrial fibrillation (AF) in patients with coronary heart disease (CHD), including those with CHF, and no effect of statin treatment on AF incidence was found.
References
More filters
Journal ArticleDOI
Right Ventricular Cardiomyopathy and Sudden Death in Young People
TL;DR: Findings indicate that right ventricular cardiomyopathy, the cause of which is still unknown, may be more frequent than previously thought and may represent an important cause of sudden death among young people in the Veneto Region of northeastern Italy.
Journal Article
Myocarditis. A histopathologic definition and classification.
HT Aretz,ME Billingham,William D. Edwards,SM Factor,John T. Fallon,Jr Jj Fenoglio,E. G. J. Olsen,Frederick J. Schoen +7 more
Journal ArticleDOI
Chronic Rapid Atrial Pacing Structural, Functional, and Electrophysiological Characteristics of a New Model of Sustained Atrial Fibrillation
TL;DR: In this article, two-dimensional echocardiography was performed in 11 dogs to assess the effects of rapid atrial pacing on atrial size, which was defined as the ability to induce sustained repetitive atrial responses during programmed electrical stimulation and was assessed by extrastimulus and burst-pacing techniqu...
Journal ArticleDOI
The natural history of lone atrial fibrillation. A population-based study over three decades.
Stephen L. Kopecky,Bernard J. Gersh,Michael D. McGoon,Jack P. Whisnant,David R. Holmes,Duane M. Ilstrup,Robert L. Frye +6 more
TL;DR: It is concluded that lone atrial fibrillation in patients under the age of 60 at diagnosis is associated with a very low risk of stroke, and routine anticoagulation may not be warranted.
Journal ArticleDOI
Characteristics and Prognosis of Lone Atrial Fibrillation: 30-Year Follow-up in the Framingham Study
TL;DR: It is suggested that subjects with lone AF, despite similar cardiovascular risk profiles to normal controls, have a distinct preponderance of preexisting electrocardiographic abnormalities.