Journal ArticleDOI
Histological Substrate of Atrial Biopsies in Patients With Lone Atrial Fibrillation
Andrea Frustaci,Cristina Chimenti,Fulvio Bellocci,Emanuela Morgante,Matteo A. Russo,Attilio Maseri +5 more
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TLDR
Abnormal atrial histology was uniformly found in multiple biopsy specimens in all patients with LAF and was compatible with a diagnosis of myocarditis in 66% of patients and of noninflammatory localized cardiomyopathy in 17% and was represented by patchy fibrosis in 17%.Abstract:
Background Lone atrial fibrillation (LAF) is a common clinical syndrome, but its origin remains unknown. Methods and Results We performed endomyocardial biopsies of the right atrial septum (2 to 3 per patient; mean, 2.8) and of the two ventricles (6 per patient) in 12 patients (10 men, 2 women; mean age, 32 years) with paroxysmal LAF refractory to conventional antiarrhythmic treatment. As controls, we used endomyocardial biopsies (3 to 5 per patient; mean, 4.4) from the right atrial septum of 11 patients with Wolff-Parkinson-White syndrome (WPW) undergoing resection of the abnormal AV pathway. The weight of the biopsies ranged from 2.8 to 4.5 mg. Biopsy samples were processed for histology and electron microscopy and were read by a pathologist blinded to clinical data. All patients underwent two-dimensional Doppler echocardiography; cardiac catheterization; coronary angiography; and hormonal, virologic, and electrophysiological studies. All tests and WPW biopsies were normal, but all LAF atrial biopsy spe...read more
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Journal ArticleDOI
Electrical, contractile and structural remodeling during atrial fibrillation
TL;DR: Both AF itself and the underlying heart disease are responsible for the development of the arrhythmogenic substrate, and the role of structural remodeling in the progression of AF is still unclear.
Journal ArticleDOI
C-Reactive Protein Elevation in Patients With Atrial Arrhythmias Inflammatory Mechanisms and Persistence of Atrial Fibrillation
Mina K. Chung,David O. Martin,Dennis L. Sprecher,Oussama M. Wazni,Anne Kanderian,Cynthia A. Carnes,John Anthony Bauer,Patrick J. Tchou,Mark Niebauer,Andrea Natale,David R. Van Wagoner +10 more
TL;DR: Elevated CRP levels in AF patients may reflect an inflammatory state that promotes the persistence of AF, and is the first to document elevated CRP in non-postoperative arrhythmia patients.
Journal ArticleDOI
Inflammation as a risk factor for atrial fibrillation
Ronnier J. Aviles,David O. Martin,Carolyn Apperson-Hansen,Penny L. Houghtaling,Pentti M. Rautaharju,Richard A. Kronmal,Russell P. Tracy,David R. Van Wagoner,Bruce M. Psaty,Michael S. Lauer,Mina K. Chung +10 more
TL;DR: CRP is not only associated with the presence of AF but may also predict patients at increased risk for future development of AF.
Journal ArticleDOI
2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS: The Task Force for the management of atrial fibrillation of the European Society of Cardiology (ESC)Developed with the special contribution of the European Heart Rhythm Association (EHRA) of the ESCEndorsed by the European Stroke Organisation (ESO)
Paulus Kirchhof,Stefano Benussi,Dipak Kotecha,Anders Ahlsson,Dan Atar,Barbara Casadei,Manuel Castellá,Hans-Christoph Diener,Hein Heidbuchel,Jeroen M.L. Hendriks,Gerhard Hindricks,Antonis S. Manolis,Jonas Oldgren,Bogdan A. Popescu,Ulrich Schotten,Bart P. van Putte,Panagiotis Vardas +16 more
TL;DR: Authors/Task Force Members: Paulus Kirchhof* (Chairperson) (UK/Germany), Stefano Benussi* (Co-Chair person) (Switzerland), Dipak Kotecha (UK), Anders Ahlsson (Sweden), Dan Atar (Norway), Barbara Casadei (UK)
Journal ArticleDOI
Atrial fibrosis: mechanisms and clinical relevance in atrial fibrillation.
Brett Burstein,Stanley Nattel +1 more
TL;DR: The current understanding of how atrial fibrosis creates a substrate for AF is reviewed, what is known about the mechanisms underlying fibrosis and its progression is summarized, and emerging therapeutic approaches aimed at attenuating structural remodeling to prevent AF are highlighted.
References
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Journal ArticleDOI
Right Ventricular Cardiomyopathy and Sudden Death in Young People
TL;DR: Findings indicate that right ventricular cardiomyopathy, the cause of which is still unknown, may be more frequent than previously thought and may represent an important cause of sudden death among young people in the Veneto Region of northeastern Italy.
Journal Article
Myocarditis. A histopathologic definition and classification.
HT Aretz,ME Billingham,William D. Edwards,SM Factor,John T. Fallon,Jr Jj Fenoglio,E. G. J. Olsen,Frederick J. Schoen +7 more
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Chronic Rapid Atrial Pacing Structural, Functional, and Electrophysiological Characteristics of a New Model of Sustained Atrial Fibrillation
TL;DR: In this article, two-dimensional echocardiography was performed in 11 dogs to assess the effects of rapid atrial pacing on atrial size, which was defined as the ability to induce sustained repetitive atrial responses during programmed electrical stimulation and was assessed by extrastimulus and burst-pacing techniqu...
Journal ArticleDOI
The natural history of lone atrial fibrillation. A population-based study over three decades.
Stephen L. Kopecky,Bernard J. Gersh,Michael D. McGoon,Jack P. Whisnant,David R. Holmes,Duane M. Ilstrup,Robert L. Frye +6 more
TL;DR: It is concluded that lone atrial fibrillation in patients under the age of 60 at diagnosis is associated with a very low risk of stroke, and routine anticoagulation may not be warranted.
Journal ArticleDOI
Characteristics and Prognosis of Lone Atrial Fibrillation: 30-Year Follow-up in the Framingham Study
TL;DR: It is suggested that subjects with lone AF, despite similar cardiovascular risk profiles to normal controls, have a distinct preponderance of preexisting electrocardiographic abnormalities.