Journal ArticleDOI
Histological Substrate of Atrial Biopsies in Patients With Lone Atrial Fibrillation
Andrea Frustaci,Cristina Chimenti,Fulvio Bellocci,Emanuela Morgante,Matteo A. Russo,Attilio Maseri +5 more
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TLDR
Abnormal atrial histology was uniformly found in multiple biopsy specimens in all patients with LAF and was compatible with a diagnosis of myocarditis in 66% of patients and of noninflammatory localized cardiomyopathy in 17% and was represented by patchy fibrosis in 17%.Abstract:
Background Lone atrial fibrillation (LAF) is a common clinical syndrome, but its origin remains unknown. Methods and Results We performed endomyocardial biopsies of the right atrial septum (2 to 3 per patient; mean, 2.8) and of the two ventricles (6 per patient) in 12 patients (10 men, 2 women; mean age, 32 years) with paroxysmal LAF refractory to conventional antiarrhythmic treatment. As controls, we used endomyocardial biopsies (3 to 5 per patient; mean, 4.4) from the right atrial septum of 11 patients with Wolff-Parkinson-White syndrome (WPW) undergoing resection of the abnormal AV pathway. The weight of the biopsies ranged from 2.8 to 4.5 mg. Biopsy samples were processed for histology and electron microscopy and were read by a pathologist blinded to clinical data. All patients underwent two-dimensional Doppler echocardiography; cardiac catheterization; coronary angiography; and hormonal, virologic, and electrophysiological studies. All tests and WPW biopsies were normal, but all LAF atrial biopsy spe...read more
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Left atrial remodelling assessed by 2D and 3D echocardiography identifies paroxysmal atrial fibrillation.
Mathieu Schaaf,Philippe Andre,Mikhail Altman,Delphine Maucort-Boulch,Joël Placide,Philippe Chevalier,Cyrille Bergerot,Hélène Thibault +7 more
TL;DR: Anatomical and functional LA remodelling assessed by 2DE and 3DE is independently and strongly associated with PAF, suggesting that these parameters can help identify PAF.
Journal ArticleDOI
Entzündung des Myokards als Arrhythmietrigger
R.M. Klein,Ernst G. Vester,M U Brehm,H. Dees,F. Picard,Dieter Niederacher,M.W. Beckmann,B. E. Strauer +7 more
TL;DR: In patients with acute or chronic myocarditis, arrhythmias are a common and often the only clinical symptom in the natural course of the disease, and further precautionary antiarrhythmic measures are necessary in patients with malignant cardiac arrh rhythmias.
Journal ArticleDOI
Epidemiology of atrial fibrillation.
TL;DR: The current evidence shows that blood pressure, hypertension and obesity seem to play a key role in the pathogenesis of atrial fibrillation, and preliminary evidence also suggests that inflammation is an important mediator of these associations.
Journal ArticleDOI
Histologic assessment of right atrial appendage myocardium in patients with atrial fibrillation after coronary artery bypass graft surgery.
Toshiko Nakai,Joby Chandy,Kazuhiko Nakai,Wayne H. Bellows,Keith Flachsbart,Randall J. Lee,Jacqueline M. Leung +6 more
TL;DR: The results suggest that the age-related atrial fibrosis rather than cellular hypertrophy may be important in the pathogenesis of AF after CABG surgery and should be further investigated.
Journal Article
Abstract 5865: The Role of Inflammation and Oxidative Stress in Atrial Fibrillation
Jie Li,Joseph F. Solus,Qingxia Chen,Young Hee Rho,Ginger L. Milne,C. Michael Stein,Dawood Darbar +6 more
TL;DR: Inflammatory biomarkers were significantly increased in patients with AF, supporting a strong association between inflammation and AF, and Surprisingly, urinary F(2)-isoprostanes, a sensitive index of systemic oxidative stress in vivo, were not increased in AF overall or in different subtypes of AF.
References
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Right Ventricular Cardiomyopathy and Sudden Death in Young People
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Journal Article
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Chronic Rapid Atrial Pacing Structural, Functional, and Electrophysiological Characteristics of a New Model of Sustained Atrial Fibrillation
TL;DR: In this article, two-dimensional echocardiography was performed in 11 dogs to assess the effects of rapid atrial pacing on atrial size, which was defined as the ability to induce sustained repetitive atrial responses during programmed electrical stimulation and was assessed by extrastimulus and burst-pacing techniqu...
Journal ArticleDOI
The natural history of lone atrial fibrillation. A population-based study over three decades.
Stephen L. Kopecky,Bernard J. Gersh,Michael D. McGoon,Jack P. Whisnant,David R. Holmes,Duane M. Ilstrup,Robert L. Frye +6 more
TL;DR: It is concluded that lone atrial fibrillation in patients under the age of 60 at diagnosis is associated with a very low risk of stroke, and routine anticoagulation may not be warranted.
Journal ArticleDOI
Characteristics and Prognosis of Lone Atrial Fibrillation: 30-Year Follow-up in the Framingham Study
TL;DR: It is suggested that subjects with lone AF, despite similar cardiovascular risk profiles to normal controls, have a distinct preponderance of preexisting electrocardiographic abnormalities.