Journal ArticleDOI
Histological Substrate of Atrial Biopsies in Patients With Lone Atrial Fibrillation
Andrea Frustaci,Cristina Chimenti,Fulvio Bellocci,Emanuela Morgante,Matteo A. Russo,Attilio Maseri +5 more
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TLDR
Abnormal atrial histology was uniformly found in multiple biopsy specimens in all patients with LAF and was compatible with a diagnosis of myocarditis in 66% of patients and of noninflammatory localized cardiomyopathy in 17% and was represented by patchy fibrosis in 17%.Abstract:
Background Lone atrial fibrillation (LAF) is a common clinical syndrome, but its origin remains unknown. Methods and Results We performed endomyocardial biopsies of the right atrial septum (2 to 3 per patient; mean, 2.8) and of the two ventricles (6 per patient) in 12 patients (10 men, 2 women; mean age, 32 years) with paroxysmal LAF refractory to conventional antiarrhythmic treatment. As controls, we used endomyocardial biopsies (3 to 5 per patient; mean, 4.4) from the right atrial septum of 11 patients with Wolff-Parkinson-White syndrome (WPW) undergoing resection of the abnormal AV pathway. The weight of the biopsies ranged from 2.8 to 4.5 mg. Biopsy samples were processed for histology and electron microscopy and were read by a pathologist blinded to clinical data. All patients underwent two-dimensional Doppler echocardiography; cardiac catheterization; coronary angiography; and hormonal, virologic, and electrophysiological studies. All tests and WPW biopsies were normal, but all LAF atrial biopsy spe...read more
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The Role of the Rho/ROCK Pathway in Ang II and TGF-β1-Induced Atrial Remodeling
Li-Juan Liu,Fengjuan Yao,Guihua Lu,Chenggui Xu,Zhe Xu,Kai Tang,Yun-Jiu Cheng,Xiuren Gao,Su-Hua Wu +8 more
TL;DR: The increased expression of profibrotic factors (CTGF, ROCK1 and Smad2/3) played an important role in the RAP-induced AF model and involved the activation of either the TGF-β1/RhoA/ROCK-1 or the T GF- β1/Smad 2/3 signaling pathway.
Journal ArticleDOI
Atrial fibrosis: an obligatory component of arrhythmia mechanisms in atrial fibrillation?
TL;DR: Human data indicate the presence of association between persistency of AF and the extent of structural changes in atrial myocardium, and the role atrial fibrosis plays in the mechanisms of AF may differ between patients with structurally normal hearts, such as lone AF, and those with advanced cardiovascular comorbidities.
Journal ArticleDOI
Proteomics of the epicardial fat secretome and its role in post-operative atrial fibrillation.
Alessandro Viviano,Xiaoke Yin,Anna Zampetaki,Marika Fava,Mark M Gallagher,Manuel Mayr,Marjan Jahangiri +6 more
TL;DR: For the first time, EAT secretome is described as a possible substrate for POAF, which contains various proteins differentially expressed in patients who later develop POAF.
Journal ArticleDOI
Splenectomy exacerbates atrial inflammatory fibrosis and vulnerability to atrial fibrillation induced by pressure overload in rats: Possible role of spleen-derived interleukin-10
Hidekazu Kondo,Naohiko Takahashi,Koro Gotoh,Akira Fukui,Shotaro Saito,Kohei Aoki,Osamu Kume,Tetsuji Shinohara,Yasushi Teshima,Tetsunori Saikawa +9 more
TL;DR: The study results suggest that SPX exacerbates AAC-induced inflammatory atrial fibrosis and increases vulnerability to AF after 4 weeks, likely because of depletion of spleen-derived IL-10.
Journal ArticleDOI
YKL-40: a new biomarker in cardiovascular disease?
Anders Bruun Mathiasen,Kristoffer Mads Aaris Henningsen,Marina Harutyunyan,Naja Dam Mygind,Jens Kastrup +4 more
TL;DR: Present knowledge on YKL-40 as a biomarker in cardiovascular disease suggests it to be most useful as a marker of disease severity, prognosis and short survival, however, future studies will evaluate whether YKl-40 can be used for monitoring of the treatment effect in different patient populations with a distinct disease diagnosis.
References
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Journal ArticleDOI
Right Ventricular Cardiomyopathy and Sudden Death in Young People
TL;DR: Findings indicate that right ventricular cardiomyopathy, the cause of which is still unknown, may be more frequent than previously thought and may represent an important cause of sudden death among young people in the Veneto Region of northeastern Italy.
Journal Article
Myocarditis. A histopathologic definition and classification.
HT Aretz,ME Billingham,William D. Edwards,SM Factor,John T. Fallon,Jr Jj Fenoglio,E. G. J. Olsen,Frederick J. Schoen +7 more
Journal ArticleDOI
Chronic Rapid Atrial Pacing Structural, Functional, and Electrophysiological Characteristics of a New Model of Sustained Atrial Fibrillation
TL;DR: In this article, two-dimensional echocardiography was performed in 11 dogs to assess the effects of rapid atrial pacing on atrial size, which was defined as the ability to induce sustained repetitive atrial responses during programmed electrical stimulation and was assessed by extrastimulus and burst-pacing techniqu...
Journal ArticleDOI
The natural history of lone atrial fibrillation. A population-based study over three decades.
Stephen L. Kopecky,Bernard J. Gersh,Michael D. McGoon,Jack P. Whisnant,David R. Holmes,Duane M. Ilstrup,Robert L. Frye +6 more
TL;DR: It is concluded that lone atrial fibrillation in patients under the age of 60 at diagnosis is associated with a very low risk of stroke, and routine anticoagulation may not be warranted.
Journal ArticleDOI
Characteristics and Prognosis of Lone Atrial Fibrillation: 30-Year Follow-up in the Framingham Study
TL;DR: It is suggested that subjects with lone AF, despite similar cardiovascular risk profiles to normal controls, have a distinct preponderance of preexisting electrocardiographic abnormalities.