Histopathological Variants of Cutaneous Squamous Cell Carcinoma: A Review
TLDR
The authors review specific histopathological features and associated clinical outcomes of the primary subdivisions of squamous cell carcinoma, a wide diversity of SCC subtypes that are associated with markedly more aggressive behaviors.Abstract:
Nonmelanoma skin cancer (NMSC) is the most common form of cancer in the Caucasian population, with squamous cell carcinoma (SCC) accounting for the majority of NMSC-related metastases and death While most SCC lesions are indolent tumors with low malignant potential, a wide diversity of SCC subtypes exist, several of which are associated with markedly more aggressive behaviors Distinguishing these high-risk variants from their counterparts is possible through microscopic analysis, since each subtype possesses unique histopathological features Early identification of high-risk lesions can allow for more rapid therapeutic intervention, reducing the likelihood of metastasis and death The authors review specific histopathological features and associated clinical outcomes of the primary subdivisions of SCCread more
Citations
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I and i
TL;DR: There is, I think, something ethereal about i —the square root of minus one, which seems an odd beast at that time—an intruder hovering on the edge of reality.
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Cutaneous Squamous Cell Carcinoma: A Review of High-Risk and Metastatic Disease
TL;DR: Treatment of metastatic cSCC is difficult and depends on the location involved and extent of metastasis, and the supporting evidence is inconsistent and a curative chemotherapeutic approach is still lacking.
Journal ArticleDOI
The importance of early diagnosis and treatment of actinic keratosis.
TL;DR: Genetic analysis demonstrates that ultraviolet radiation-induced mutations and changes in gene expression are present in squamous cell carcinoma, AK, and clinically normal-appearing perilesional sun-exposed skin, which supports the progressive nature of keratinocyte transformation.
Journal ArticleDOI
The DNA damage checkpoint precedes activation of ARF in response to escalating oncogenic stress during tumorigenesis.
Konstantinos Evangelou,Jirina Bartkova,A. Kotsinas,Ioannis S. Pateras,Michalis Liontos,Georgia Velimezi,Martin Kosar,Triantafillos Liloglou,Ioannis P. Trougakos,Lars Dyrskjøt,Claus L. Andersen,Marilena Papaioannou,Yiannis Drosos,George Papafotiou,Zdenek Hodny,Beatriz Sosa-Pineda,Xue-Ru Wu,Apostolos Klinakis,Torben F. Ørntoft,Jiri Lukas,Jiri Bartek,Jiri Bartek,Vassilis G. Gorgoulis,Vassilis G. Gorgoulis +23 more
TL;DR: It is proposed that relative to DDR activation, ARF provides a complementary and delayed barrier to tumor development, responding to more robust stimuli of escalating oncogenic overload.
Oral florid papillomatosis or verrucous carcinoma
TL;DR: Florid Papillomatosis (FP) is another form of verrucous carcinoma as mentioned in this paper, and it can be found in the larynx, nose, genitalia, skin, etc.
References
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Journal ArticleDOI
I and i
TL;DR: There is, I think, something ethereal about i —the square root of minus one, which seems an odd beast at that time—an intruder hovering on the edge of reality.
Journal ArticleDOI
The epidemiology of skin cancer.
Thomas L. Diepgen,V Mahler +1 more
TL;DR: Melanoma and non‐melanoma (basal and squamous cell carcinoma) skin cancer (NMSC) are now the most common types of cancer in the white populations and the incidence of skin cancer has reached epidemic proportions.
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Prognostic factors for local recurrence, metastasis, and survival rates in squamous cell carcinoma of the skin, ear, and lip : implications for treatment modality selection
TL;DR: All studies since 1940 on the prognosis of squamous cell carcinoma of the skin and lip are reviewed, finding local recurrences occur less frequently when SCC is treated by Mohs micrographic surgery.
Journal ArticleDOI
Cutaneous Squamous-Cell Carcinoma
Murad Alam,Désirée Ratner +1 more
TL;DR: Nonmelanoma skin cancer is the most common cancer in the United States, with over 1.3 million cases expected to occur in the year 2001 and cutaneous squamous-cell carcinomas are associated with a substantial risk of metastasis.