Journal ArticleDOI
“Homology” in proteins and nucleic acids: A terminology muddle and a way out of it
Gerald R. Reeck,Christoph de Haën,David C. Teller,Russell F. Doolittle,Walter M. Fitch,Richard E. Dickerson,Pierre Chambon,A.D. McLachlan,Emanuel Margoliash,Thomas H. Jukes,Emile Zuckerkandl +10 more
TLDR
It is believed that the concepts of evolutionary homology and sequence or three-dimensional similarity can be kept distinct only if they are referred to with different words.About:
This article is published in Cell.The article was published on 1987-08-28. It has received 403 citations till now.read more
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MEROPS: the peptidase database
TL;DR: The MEROPS database has added an analysis tool to the relevant species pages to show significant gains and losses of peptidase genes relative to related species, and has collected over 39 000 known cleavage sites in proteins, peptides and synthetic substrates.
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Orthologs, Paralogs, and Evolutionary Genomics 1
TL;DR: This review examines in depth the definitions and subtypes of orthologs and paralogs, outlines the principal methodological approaches employed for identification of orthology and paralogy, and considers evolutionary and functional implications of these concepts.
Patent
Method for reducing the immunogenicity of antibody variable domains
TL;DR: In this paper, a unique method was disclosed for identifying and replacing immunoglobulin surface amino acid residues which converted the antigenicity of a first mammalian species to that of a second mammalian species.
Journal ArticleDOI
Evolutionary families of peptidases
Neil D. Rawlings,Alan J. Barrett +1 more
TL;DR: It is suggested that the classification by families could be used as an extension of the current classification by catalytic type, and some of these contain members with quite diverse peptidase activities.
Journal ArticleDOI
Homology: a personal view on some of the problems
TL;DR: This work examines 15 terminological problems related to the usage of homology and its associated terms and suggests a set of definitions that are intended to be totally consistent among themselves and also as consistent as possible with most current usage.